Reaction profile

The FDA adverse-event record for corneal ulcer

1,015 FDA adverse-event reports reference corneal ulcer (VeDDRA 415). See the species, breeds, and drugs most associated with it below.

1,015
reports citing this reaction
9.3%
death-coded share
Dog
most-affected species
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride
most-associated drug
Verify with FDA CVM →
1,015
Total Reports
94
Deaths
9.3%
Death Rate

Species Most Affected

Dog 879
Cat 100
Horse 12
Human 11
Cattle 9
Mouse 1
Hedgehog 1
Guinea Pig 1
Rabbit 1

Breeds Most Affected

Shih Tzu 117
Chihuahua 76
Domestic Shorthair 47
Retriever - Labrador 36
Terrier - Yorkshire 36
Maltese 35
Bulldog - French 34
Terrier - Boston 32
Crossbred Canine/dog 29
Bichon Frise 23

Associated Drugs

Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 232
Oclacitinib Maleate 127
Maropitant Citrate 87
Trilostane 74
Carprofen 71
Milbemycin Oxime + Spinosad 69
Prednisone 64
Gabapentin 58
Enrofloxacin 51
Buprenorphine 44
Ofloxacin 43
Cyclosporine 41
Pilocarpine 41
Tobramycin 39
Betamethasone + Florfenicol + Terbinafine 38
Meloxicam 37
Florfenicol, Terbinafine, Betamethasone Acetate 34
Ear Cleaner 31
Cefovecin Sodium 30
Imidacloprid + Moxidectin 29

Corneal ulcer Reaction Insights

1,015 reports name Corneal ulcer; 94 recorded a death outcome (9.3% of reported events, not a population-level mortality rate). VeDDRA code: 415.

By species: Dog (879 reports), Cat (100 reports), Horse (12 reports). By breed: Shih Tzu (117), Chihuahua (76), Domestic Shorthair (47).

Most co-reported drugs: Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (232 reports), Oclacitinib Maleate (127 reports), Maropitant Citrate (87 reports), Trilostane (74 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.