Reaction profile

The FDA adverse-event record for corneal ulcer

1,054 FDA reports name corneal ulcer, a high-volume reaction in the CVM extract (VeDDRA 415). Plate stamps and neighbourhood peers follow.

#377 of 2,481
by report volume (all reactions)
1,054
reports citing this reaction
9.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Corneal ulcer has 1,054 reports now versus 1,036 in that prior snapshot: 18 more (1.7%).

Report change
+18
Death-coded reports
+5
Death-coded share
+0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Corneal ulcer changes

FDA AER · VeDDRA plate

Code 415 VOL-MID

VOL-MID · DEATH-PAR · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,054 reports
  • DEATH-PAR 9.9%
  • UPPER-Q #377/2481
  • PHOTO-FINISH Elevated creatine-kin…
  • SPECIES-DOG Dog · 910
  • DRUG-LEAD Florfenicol + Mom… · 239
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Elevated creatine-kinase (CK) (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Corneal ulcer

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348INEFFECTIVE, ANTIINFL… · near1059Corneal ulcer · this reaction1054Elevated creatine-kin… · near1053Discoloured urine · near1051Eye redness · near1050Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Corneal ulcer

What the FDA AER plate says about Corneal ulcer

Signature read: 1,054 reports place Corneal ulcer in the upper third of FDA AER volume (#377 of 2,481). Report volume is upper-third scale: 1,054 named reports in the openFDA extract. 104 of 1,054 reports were death-coded (9.9% of named reports, not a population mortality rate). Nearest volume peer: Elevated creatine-kinase (CK) (±1 reports). Lead species Dog (910). Lead co-reported drug Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (239).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 910
Cat 106
Horse 13
Human 12
Cattle 9
Mouse 1
Hedgehog 1
Guinea Pig 1
Rabbit 1

Breeds Most Affected

Shih Tzu 120
Chihuahua 78
Domestic Shorthair 51
Retriever - Labrador 40
Terrier - Yorkshire 38
Bulldog - French 36
Maltese 36
Terrier - Boston 33
Crossbred Canine/dog 30
Bichon Frise 24

Associated Drugs

Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 239
Oclacitinib Maleate 127
Maropitant Citrate 93
Carprofen 80
Trilostane 74
Milbemycin Oxime + Spinosad 69
Prednisone 64
Gabapentin 63
Enrofloxacin 53
Buprenorphine 50
Ofloxacin 49
Pilocarpine 45
Cyclosporine 42
Meloxicam 39
Tobramycin 39
Betamethasone + Florfenicol + Terbinafine 38
Florfenicol, Terbinafine, Betamethasone Acetate 36
Bedinvetmab 32
Cefovecin Sodium 31
Ear Cleaner 31

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Corneal ulcer, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (9.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Corneal ulcer (#377 of 2,481 by report volume); death-coded 9.9%. PlainBreed reaction plate · report volume stamp 1,054 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →