Reaction profile

The FDA adverse-event record for discoloured urine

1,051 FDA reports name discoloured urine, a high-volume reaction in the CVM extract (VeDDRA 1964). Plate stamps and neighbourhood peers follow.

#379 of 2,481
by report volume (all reactions)
1,051
reports citing this reaction
24.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Discoloured urine has 1,051 reports now versus 1,035 in that prior snapshot: 16 more (1.5%).

Report change
+16
Death-coded reports
+7
Death-coded share
+0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Discoloured urine changes

FDA AER · VeDDRA plate

Code 1964 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,051 reports
  • DEATH-HOT 24.4%
  • UPPER-Q #379/2481
  • PHOTO-FINISH Eye redness
  • SPECIES-DOG Dog · 915
  • DRUG-LEAD Carprofen · 257
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Eye redness (±1 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Discoloured urine

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Corneal ulcer · near1054Elevated creatine-kin… · near1053Discoloured urine · this rea…1051Eye redness · near1050Licking at applicatio… · near1049Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Discoloured urine

Discoloured urine: high death-coded share in the FDA AER plate

Signature read: 256 death-coded reports is a heavy tail count for Discoloured urine in the CVM extract. Report volume is upper-third scale: 1,051 named reports in the openFDA extract. Death-coded share is upper-third: 256 of 1,051 reports (24.4% of named reports). Nearest volume peer: Eye redness (±1 reports). Lead species Dog (915). Lead co-reported drug Carprofen (257).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 915
Cat 89
Horse 33
Cattle 5
Goat 4
Human 3
Pig 1
Rabbit 1

Breeds Most Affected

Retriever - Labrador 153
Crossbred Canine/dog 64
Domestic Shorthair 55
Chihuahua 45
Shepherd Dog - German 40
Dog (unknown) 32
Shih Tzu 32
Retriever - Golden 28
Terrier - Yorkshire 28
Maltese 22

Associated Drugs

Carprofen 257
Maropitant Citrate 75
Milbemycin Oxime + Spinosad 68
Moxidectin 49
Ivermectin + Pyrantel As Pamoate Salt 46
Afoxolaner 45
Bedinvetmab 39
Enrofloxacin 38
Pyrantel Pamoate;Sarolaner 36
Meloxicam 34
Oclacitinib Maleate 34
Fluralaner Chew Tablets 31
Gabapentin 30
Spinosad 29
Famotidine 29
Cefovecin 28
Prednisone 26
Deracoxib 25
Tramadol 25
Metronidazole 25

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Discoloured urine, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,051 here).

Similar death-coded share

Nearest other reactions by death-coded share (24.4% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Discoloured urine (#379 of 2,481 by report volume); death-coded 24.4%. PlainBreed reaction plate · death-coded report count stamp 256 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →