Reaction profile

The FDA adverse-event record for premature ventricular contractions

Name: Premature ventricular contractions - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

175 FDA adverse-event reports reference premature ventricular contractions (VeDDRA 2434). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1109 of 2,481
by report volume (all reactions): 175
reports citing this reaction: 22.3%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Premature ventricular contractions has 175 reports now versus 167 in that prior snapshot: 8 more (4.8%).

Report change: +8
Death-coded reports: +3
Death-coded share: +0.7 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Premature ventricular contractions changes

FDA AER · VeDDRA plate

Code 2434 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-LOW 175 reports
DEATH-HOT 22.3%
MID-PACK #1109/2481
PHOTO-FINISH Elevated lactate
SPECIES-DOG Dog · 154
DRUG-LEAD Dexmedetomidine H… · 37
DESK-WIDE 20 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Elevated lactate (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Premature ventricular contractions

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

FDA AER report volume · neighbourhood around Premature ventricular contractions

What the FDA AER plate says about Premature ventricular contractions

Signature read: 39 death-coded reports is the most distinctive absolute-outcome stamp on Premature ventricular contractions. Report volume sits in the middle third of the reaction corpus. 39 of 175 reports were death-coded (22.3% of named reports, not a population mortality rate). Nearest volume peer: Elevated lactate (±0 reports). Lead species Dog (154). Lead co-reported drug Dexmedetomidine Hydrochloride (37).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Dexmedetomidine Hydrochloride appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 154

Cat 20

Guinea Pig 1

Breeds Most Affected

Retriever - Labrador 25

Crossbred Canine/dog 14

Boxer (German Boxer) 12

Domestic Shorthair 11

Shepherd Dog - German 9

Terrier - Bull - American Pit 7

Retriever - Golden 6

Dog (unknown) 6

Maine Coon 4

Collie - Border 3

Associated Drugs

Dexmedetomidine Hydrochloride 37

Propofol 30

Maropitant Citrate 28

Isoflurane 27

Butorphanol 21

Carprofen 17

Dexmedetomidine 16

Gabapentin 13

Buprenorphine 12

Bedinvetmab 11

Oclacitinib Maleate 10

Atipamezole Hydrochloride 10

Ketamine 10

Moxidectin 10

Diphenhydramine 10

Hydromorphone 8

Pyrantel Pamoate;Sarolaner 7

Alfaxalone 7

Tigilanol Tiglate 7

Butorphanol Tartrate 7

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Premature ventricular contractions, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (175 here).

Elevated lactate 175 HEMOGLOBIN(HB) HIGH, BLOOD 175 Hepatic neoplasm 175 PR-LYMPH NODE(S), LESION(S) 175

Similar death-coded share

Nearest other reactions by death-coded share (22.3% here), distinct from the volume row.

Neurological symptoms NOS 22.3% Elevated creatine-kinase (CK) 22.3% Heavy breathing 22.2% Increased drinking 22.2%

What to do with this reaction

Compare Premature ventricular contractions's report profile against similar reactions nationwide. See similar reactions
Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Premature ventricular contractions (#1109 of 2,481 by report volume); death-coded 22.3%. PlainBreed reaction plate · death-coded report count stamp 39 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →