Reaction profile

The FDA adverse-event record for eye redness

1,018 FDA adverse-event reports reference eye redness (VeDDRA 457). See the species, breeds, and drugs most associated with it below.

1,018
reports citing this reaction
3.7%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
1,018
Total Reports
38
Deaths
3.7%
Death Rate

Species Most Affected

Dog 727
Human 205
Cat 81
Horse 2
Cattle 2
Goat 1

Breeds Most Affected

Unknown 206
Retriever - Labrador 57
Crossbred Canine/dog 56
Boxer (German Boxer) 40
Domestic Shorthair 39
Shih Tzu 34
Chihuahua 31
Pit Bull 27
Dachshund (unspecified) 23
Retriever - Golden 21

Associated Drugs

Milbemycin Oxime + Spinosad 128
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 72
Moxidectin 67
Imidacloprid + Moxidectin 47
Selamectin 41
Carprofen 39
Spinosad 38
Maropitant Citrate 37
Meloxicam 27
Enrofloxacin 26
Oclacitinib Maleate 26
Cyclosporine 22
Prednisone 22
Pyrantel Pamoate;Sarolaner 21
Afoxolaner 20
Cefovecin 17
Buprenorphine 14
Ivermectin 13
Tresaderm Dermatological Solution 13
Dexamethasone 13

Eye redness Reaction Insights

1,018 reports name Eye redness; 38 recorded a death outcome (3.7% of reported events, not a population-level mortality rate). VeDDRA code: 457.

By species: Dog (727 reports), Human (205 reports), Cat (81 reports). By breed: Unknown (206), Retriever - Labrador (57), Crossbred Canine/dog (56).

Most co-reported drugs: Milbemycin Oxime + Spinosad (128 reports), Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (72 reports), Moxidectin (67 reports), Imidacloprid + Moxidectin (47 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.