Reaction profile

The FDA adverse-event record for discus prolapse

108 FDA adverse-event reports reference discus prolapse (VeDDRA 599). See the species, breeds, and drugs most associated with it below.

108
reports citing this reaction
23.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
108
Total Reports
25
Deaths
23.1%
Death Rate

Species Most Affected

Dog 107
Cat 1

Breeds Most Affected

Retriever - Labrador 12
Dachshund (unspecified) 9
Crossbred Canine/dog 8
Schnauzer (unspecified) 5
Dachshund - Miniature 5
Bulldog - French 5
Shepherd Dog - German 4
Terrier - Yorkshire 4
Spaniel - Cocker American 3
Shih Tzu 3

Associated Drugs

Milbemycin Oxime + Spinosad 30
Spinosad 15
Trilostane 15
Carprofen 14
Gabapentin 9
Bedinvetmab 8
Cyclosporine 4
Meloxicam 4
Oclacitinib Maleate 4
Methocarbamol 3
Selamectin 3
Prednisone 3
Afoxolaner 3
Milbemycin Oxime 3
Milbemycin Oxime + Praziquantel 3
Fluralaner 13.64% 12-Week Chew 3
Deracoxib 2
Nitenpyram 2
Alprazolam 2
Vaccines (Unknown) 2

Discus prolapse Reaction Insights

108 reports name Discus prolapse; 25 recorded a death outcome (23.1% of reported events, not a population-level mortality rate). VeDDRA code: 599.

By species: Dog (107 reports), Cat (1 reports). By breed: Retriever - Labrador (12), Dachshund (unspecified) (9), Crossbred Canine/dog (8).

Most co-reported drugs: Milbemycin Oxime + Spinosad (30 reports), Spinosad (15 reports), Trilostane (15 reports), Carprofen (14 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.