Reaction profile

The FDA adverse-event record for heart pounding

105 FDA adverse-event reports reference heart pounding (VeDDRA 1514). See the species, breeds, and drugs most associated with it below.

105
reports citing this reaction
12.4%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
105
Total Reports
13
Deaths
12.4%
Death Rate

Species Most Affected

Dog 89
Human 7
Cat 6
Horse 2
Cattle 1

Breeds Most Affected

Chihuahua 7
Unknown 7
Retriever - Golden 4
Schnauzer - Miniature 4
Retriever - Labrador 4
Crossbred Canine/dog 4
Shih Tzu 4
Maltese 3
Dachshund (unspecified) 3
Shepherd Dog - Australian 3

Associated Drugs

Milbemycin Oxime + Spinosad 28
Pimobendan 25
Milbemycin Oxime + Praziquantel 6
Furosemide 5
Afoxolaner 5
Pyrantel Pamoate;Sarolaner 5
Spinosad 4
Carprofen 4
Benazepril 3
Enalapril 3
Cefovecin 3
Gabapentin 3
Rabies Vaccine 2
Bordetella Vaccine 2
Enalapril Maleate 2
Nitenpyram 2
Ivermectin + Pyrantel As Pamoate Salt 2
Phenylpropanolamine Hcl 2
Trilostane 2
Phenylpropropanolamine Hcl 2

Heart pounding Reaction Insights

105 reports name Heart pounding; 13 recorded a death outcome (12.4% of reported events, not a population-level mortality rate). VeDDRA code: 1514.

By species: Dog (89 reports), Human (7 reports), Cat (6 reports). By breed: Chihuahua (7), Unknown (7), Retriever - Golden (4).

Most co-reported drugs: Milbemycin Oxime + Spinosad (28 reports), Pimobendan (25 reports), Milbemycin Oxime + Praziquantel (6 reports), Furosemide (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.