Reaction profile

The FDA adverse-event record for lick granuloma

97 FDA adverse-event reports reference lick granuloma (VeDDRA 2264). See the species, breeds, and drugs most associated with it below.

97
reports citing this reaction
6.2%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
97
Total Reports
6
Deaths
6.2%
Death Rate

Species Most Affected

Dog 94
Cat 3

Breeds Most Affected

Retriever - Labrador 19
Retriever - Golden 9
Beagle 7
Shepherd Dog - German 7
Shepherd Dog - Australian 6
Doberman Pinscher 5
Crossbred Canine/dog 5
Collie - Border 3
Domestic Shorthair 3
Terrier (unspecified) 3

Associated Drugs

Milbemycin Oxime + Spinosad 28
Oclacitinib Maleate 25
Bedinvetmab 15
Deracoxib 7
Afoxolaner 6
Gabapentin 6
Rabies Vaccine 5
Bordetella Vaccine 5
Levothyroxine 4
Cefpodoxime 4
Carprofen 4
Milbemycin Oxime + Praziquantel 4
Prednisone 4
Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 4
Fluralaner 4
Fluralaner Chew Tablets 3
Diphenhydramine Hcl 3
Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Borrelia Burgdorferi Bacterin-Lepto Cani-Grippo-Ictero-Pomona Bacterial Extract 3
Doxycycline 3
Lotilaner 3

Lick granuloma Reaction Insights

97 reports name Lick granuloma; 6 recorded a death outcome (6.2% of reported events, not a population-level mortality rate). VeDDRA code: 2264.

By species: Dog (94 reports), Cat (3 reports). By breed: Retriever - Labrador (19), Retriever - Golden (9), Beagle (7).

Most co-reported drugs: Milbemycin Oxime + Spinosad (28 reports), Oclacitinib Maleate (25 reports), Bedinvetmab (15 reports), Deracoxib (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.