Reaction profile

The FDA adverse-event record for limpness

487 FDA reports name limpness, a high-volume reaction in the CVM extract (VeDDRA 2252). Plate stamps and neighbourhood peers follow.

#653 of 2,481
by report volume (all reactions)
487
reports citing this reaction
23.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Limpness has 487 reports now versus 469 in that prior snapshot: 18 more (3.8%).

Report change
+18
Death-coded reports
+0
Death-coded share
−0.9 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Limpness changes

FDA AER · VeDDRA plate

Code 2252 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 487 reports
  • DEATH-HOT 23.2%
  • MID-PACK #653/2481
  • PHOTO-FINISH Septicaemia
  • SPECIES-DOG Dog · 364
  • DRUG-LEAD Moxidectin · 48
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Septicaemia (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Limpness

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Sickness · near491Application site resi… · near490Stiff gait · near489Limpness · this reaction487Septicaemia · near487Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Limpness

What the FDA AER plate says about Limpness

Signature read: 113 death-coded reports is a heavy tail count for Limpness in the CVM extract. Report volume is upper-third scale: 487 named reports in the openFDA extract. 113 of 487 reports were death-coded (23.2% of named reports, not a population mortality rate). Nearest volume peer: Septicaemia (±0 reports). Lead species Dog (364). Lead co-reported drug Moxidectin (48).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Moxidectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 364
Cat 116
Snake 2
Ferret 1
Guinea Pig 1
Goat 1
Alpaca 1
Rat 1

Breeds Most Affected

Domestic Shorthair 70
Chihuahua 38
Terrier - Yorkshire 33
Shih Tzu 30
Crossbred Canine/dog 22
Maltese 18
Retriever - Labrador 15
Spitz - German Pomeranian 12
Terrier (unspecified) 11
Schnauzer - Miniature 10

Associated Drugs

Moxidectin 48
Milbemycin Oxime + Spinosad 45
Maropitant Citrate 34
Pyrantel Pamoate;Sarolaner 30
Cefovecin 28
Afoxolaner 26
Fluralaner 13.64% 12-Week Chew 21
Gabapentin 20
Bedinvetmab 19
Nitenpyram 17
Rabies Vaccine 16
Selamectin 16
Imidacloprid + Moxidectin 15
Ivermectin + Pyrantel As Pamoate Salt 15
Fluralaner Chew Tablets 15
Carprofen 14
Rabies Virus, Kv 13
Spinosad 12
Frunevetmab 11
Trilostane 10

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Limpness, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (487 here).

Similar death-coded share

Nearest other reactions by death-coded share (23.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Limpness (#653 of 2,481 by report volume); death-coded 23.2%. PlainBreed reaction plate · death-coded report count stamp 113 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →