Reaction profile

The FDA adverse-event record for limpness

452 FDA adverse-event reports reference limpness (VeDDRA 2252). See the species, breeds, and drugs most associated with it below.

452
reports citing this reaction
23.9%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
452
Total Reports
108
Deaths
23.9%
Death Rate

Species Most Affected

Dog 341
Cat 105
Snake 2
Ferret 1
Guinea Pig 1
Goat 1
Alpaca 1

Breeds Most Affected

Domestic Shorthair 63
Chihuahua 36
Terrier - Yorkshire 32
Shih Tzu 29
Crossbred Canine/dog 19
Maltese 17
Retriever - Labrador 14
Spitz - German Pomeranian 11
Terrier (unspecified) 10
Terrier - Jack Russell 9

Associated Drugs

Moxidectin 45
Milbemycin Oxime + Spinosad 44
Maropitant Citrate 29
Cefovecin 27
Pyrantel Pamoate;Sarolaner 27
Afoxolaner 26
Fluralaner 13.64% 12-Week Chew 21
Gabapentin 19
Bedinvetmab 18
Selamectin 16
Nitenpyram 16
Imidacloprid + Moxidectin 15
Fluralaner Chew Tablets 15
Ivermectin + Pyrantel As Pamoate Salt 14
Rabies Vaccine 14
Spinosad 12
Rabies Virus, Kv 12
Carprofen 12
Trilostane 10
Milbemycin Oxime + Praziquantel 9

Limpness Reaction Insights

452 reports name Limpness; 108 recorded a death outcome (23.9% of reported events, not a population-level mortality rate). VeDDRA code: 2252.

By species: Dog (341 reports), Cat (105 reports), Snake (2 reports). By breed: Domestic Shorthair (63), Chihuahua (36), Terrier - Yorkshire (32).

Most co-reported drugs: Moxidectin (45 reports), Milbemycin Oxime + Spinosad (44 reports), Maropitant Citrate (29 reports), Cefovecin (27 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.