Reaction profile
The FDA adverse-event record for acid-base disorder
108 FDA adverse-event reports reference acid-base disorder (VeDDRA 540). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.
- #1349 of 2,481
- by report volume (all reactions)
- 108
- reports citing this reaction
- 31.5%
- death-coded share
- Dog
- most-affected species
Release-over-release change
What changed in the latest FDA data snapshot
PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Acid-base disorder has 108 reports now versus 101 in that prior snapshot: 7 more (6.9%).
- Report change
- +7
- Death-coded reports
- +1
- Death-coded share
- −1.2 pts
This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.
Subscribe to Acid-base disorder changesFDA AER · VeDDRA plate
Code 540 VOL-LOW
VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL
- VOL-LOW 108 reports
- DEATH-HOT 31.5%
- MID-PACK #1349/2481
- PHOTO-FINISH Discus prolapse
- SPECIES-DOG Dog · 54
- DRUG-LEAD Velagliflozin Pro… · 35
- DESK-WIDE 20 breeds
- BOOK-FULL 8/8 fields
Nearest volume peer: Discus prolapse (±0 reports)
Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.
Report-volume neighbourhood around Acid-base disorder
Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.
Acid-base disorder: high death-coded share in the FDA AER plate
Signature read: Acid-base disorder's 31.5% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 34 of 108 reports (31.5% of named reports). Nearest volume peer: Discus prolapse (±0 reports). Lead species Dog (54). Lead co-reported drug Velagliflozin Proline Monohydrate (35).
Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.
Species Most Affected
Breeds Most Affected
Associated Drugs
Nationwide reactions with similar profiles
Two openFDA-derived peer sets for Acid-base disorder, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).
Similar report volume
Nearest other reactions by FDA report count (108 here).
Similar death-coded share
Nearest other reactions by death-coded share (31.5% here), distinct from the volume row.
What to do with this reaction
- Compare Acid-base disorder's report profile against similar reactions nationwide. See similar reactions
- Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
- Browse the full reaction directory to compare report counts across reaction types. All reactions
A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.
Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025
Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →