Reaction profile

The FDA adverse-event record for acid-base disorder

88 FDA adverse-event reports reference acid-base disorder (VeDDRA 540). See the species, breeds, and drugs most associated with it below.

88
reports citing this reaction
31.8%
death-coded share
Dog
most-affected species
Velagliflozin Proline Monohydrate
most-associated drug
Verify with FDA CVM →
88
Total Reports
28
Deaths
31.8%
Death Rate

Species Most Affected

Dog 51
Cat 35
Horse 1
Other 1

Breeds Most Affected

Domestic Shorthair 25
Domestic Longhair 5
Retriever - Labrador 3
Chihuahua 3
Retriever - Golden 3
Unknown 3
Domestic Mediumhair 3
Dog (other) 2
Shepherd Dog - German 2
Chow Chow 2

Associated Drugs

Velagliflozin Proline Monohydrate 24
Carprofen 14
Gabapentin 9
Afoxolaner 7
Enrofloxacin 6
Propofol 6
Diphenhydramine 6
Milbemycin Oxime + Spinosad 5
Ivermectin + Pyrantel As Pamoate Salt 5
Butorphanol 5
Maropitant 5
Famotidine 5
Dexmedetomidine 4
Oxygen 4
Tigilanol Tiglate 4
Firocoxib 227 Mg Chewable 3
Dexamethasone 3
Ketamine Hydrochloride 3
Vaccine 3
Meloxicam 3

Acid-base disorder Reaction Insights

88 reports name Acid-base disorder; 28 recorded a death outcome (31.8% of reported events, not a population-level mortality rate). VeDDRA code: 540.

By species: Dog (51 reports), Cat (35 reports), Horse (1 reports). By breed: Domestic Shorthair (25), Domestic Longhair (5), Retriever - Labrador (3).

Most co-reported drugs: Velagliflozin Proline Monohydrate (24 reports), Carprofen (14 reports), Gabapentin (9 reports), Afoxolaner (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.