Reaction profile

The FDA adverse-event record for digestive tract disorder nos

22,748 FDA reports name digestive tract disorder nos, a high-volume reaction in the CVM extract (VeDDRA 305). Plate stamps and neighbourhood peers follow.

#15 of 2,481
by report volume (all reactions)
22,748
reports citing this reaction
3.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Digestive tract disorder NOS has 22,748 reports now versus 22,719 in that prior snapshot: 29 more (0.1%).

Report change
+29
Death-coded reports
+3
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Digestive tract disorder NOS changes

FDA AER · VeDDRA plate

Code 305 VOL-HIGH

VOL-HIGH · DEATH-LOW · TOP-DECILE · NEAR-PEER · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-HIGH 22,748 reports
  • DEATH-LOW 3.0%
  • TOP-DECILE #15/2481
  • NEAR-PEER Ataxia
  • SPECIES-DOG Dog · 21,985
  • DRUG-LEAD Ivermectin + Pyra… · 13,029
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Ataxia (±1,122 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Digestive tract disorder NOS

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Behavioural disorder… · near24337Digestive tract disor… · thi…22748Ataxia · near21626Other abnormal test r… · near21162Death by euthanasia · near21034Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Digestive tract disorder NOS

Digestive tract disorder NOS: low death-coded share in the FDA AER plate

Signature read: 22,748 reports place Digestive tract disorder NOS in the upper third of FDA AER volume (#15 of 2,481). Report volume is upper-third scale: 22,748 named reports in the openFDA extract. Death-coded share is lower-third: 678 of 22,748 reports (3.0% of named reports). Nearest volume peer: Ataxia (±1,122 reports). Lead species Dog (21,985). Lead co-reported drug Ivermectin + Pyrantel As Pamoate Salt (13,029).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Ivermectin + Pyrantel As Pamoate Salt appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 21,985
Cat 411
Cattle 151
Horse 97
Human 29
Chicken 22
Pig 20
Sheep 11
Turkey 3
Unknown 3

Breeds Most Affected

Retriever - Labrador 3,656
Crossbred Canine/dog 2,008
Retriever - Golden 1,646
Beagle 1,016
Shepherd Dog - German 881
Dog (unknown) 531
Greyhound 528
Boxer (German Boxer) 508
Shih Tzu 498
Terrier - Yorkshire 376

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 13,029
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 2,623
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 1,712
Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg 1,416
Milbemycin Oxime + Spinosad 524
Ivermectin/Pyrantel Chew. Dog 272Mcg/227Mg 503
Ivermectin/Pyrantel Chew. Dog 68Mcg/57Mg 327
Ivermectin/Pyrantel Chew. Dog 136Mcg/114Mg 265
Carprofen 247
Maropitant Citrate 223
Afoxolaner 208
Spinosad 168
Milbemycin Oxime + Praziquantel 130
Oclacitinib Maleate 123
Ivermectin 94
Selamectin 88
Cyclosporine 83
Metronidazole 79
Famotidine 77
Deracoxib 75

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Digestive tract disorder NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (22,748 here).

Similar death-coded share

Nearest other reactions by death-coded share (3.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Digestive tract disorder NOS (#15 of 2,481 by report volume); death-coded 3.0%. PlainBreed reaction plate · report volume stamp 22,748 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →