Reaction profile

The FDA adverse-event record for digestive tract disorder nos

22,675 FDA adverse-event reports reference digestive tract disorder nos (VeDDRA 305). See the species, breeds, and drugs most associated with it below.

22,675
reports citing this reaction
2.9%
death-coded share
Dog
most-affected species
Ivermectin + Pyrantel As Pamoate Salt
most-associated drug
Verify with FDA CVM →
22,675
Total Reports
666
Deaths
2.9%
Death Rate

Species Most Affected

Dog 21,931
Cat 396
Cattle 150
Horse 96
Human 29
Chicken 22
Pig 19
Sheep 11
Unknown 3
Goat 3

Breeds Most Affected

Retriever - Labrador 3,652
Crossbred Canine/dog 2,002
Retriever - Golden 1,645
Beagle 1,016
Shepherd Dog - German 879
Greyhound 528
Dog (unknown) 525
Boxer (German Boxer) 508
Shih Tzu 495
Terrier - Yorkshire 375

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 13,024
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 2,623
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 1,711
Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg 1,416
Milbemycin Oxime + Spinosad 523
Ivermectin/Pyrantel Chew. Dog 272Mcg/227Mg 503
Ivermectin/Pyrantel Chew. Dog 68Mcg/57Mg 327
Ivermectin/Pyrantel Chew. Dog 136Mcg/114Mg 265
Carprofen 243
Maropitant Citrate 216
Afoxolaner 207
Spinosad 168
Milbemycin Oxime + Praziquantel 126
Oclacitinib Maleate 119
Ivermectin 94
Selamectin 88
Cyclosporine 79
Metronidazole 77
Famotidine 77
Deracoxib 75

Digestive tract disorder NOS Reaction Insights

22,675 reports name Digestive tract disorder NOS; 666 recorded a death outcome (2.9% of reported events, not a population-level mortality rate). VeDDRA code: 305.

By species: Dog (21,931 reports), Cat (396 reports), Cattle (150 reports). By breed: Retriever - Labrador (3,652), Crossbred Canine/dog (2,002), Retriever - Golden (1,645).

Most co-reported drugs: Ivermectin + Pyrantel As Pamoate Salt (13,024 reports), Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg (2,623 reports), Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg (1,711 reports), Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg (1,416 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.