Reaction profile

The FDA adverse-event record for hair coat discolouration

618 FDA adverse-event reports reference hair coat discolouration (VeDDRA 1187). See the species, breeds, and drugs most associated with it below.

618
reports citing this reaction
3.1%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
618
Total Reports
19
Deaths
3.1%
Death Rate

Species Most Affected

Dog 487
Cat 77
Horse 44
Cattle 8
Sheep 1
Ferret 1

Breeds Most Affected

Retriever - Labrador 33
Domestic Shorthair 32
Crossbred Canine/dog 29
Shih Tzu 25
Retriever - Golden 23
Maltese 20
Dog (unknown) 19
Bichon Frise 16
Shepherd Dog - German 15
Chihuahua 14

Associated Drugs

Oclacitinib Maleate 60
Selamectin 50
Milbemycin Oxime + Spinosad 47
Trilostane 34
Polysulfated Glycosaminoglycan 33
Afoxolaner 28
Cyclosporine 25
Spinosad 25
Fipronil 10%/S Methoprene 9% Spot On 25
Ivermectin + Pyrantel As Pamoate Salt 25
Imidacloprid + Moxidectin 24
Prednisone 20
Fluralaner Chew Tablets 20
Cyclosporine A 17
Toceranib Phosphate 14
Carprofen 14
Bedinvetmab 13
Moxidectin 12
Desoxycorticosterone Pivalate 11
Pyrantel Pamoate;Sarolaner 11

Hair coat discolouration Reaction Insights

618 reports name Hair coat discolouration; 19 recorded a death outcome (3.1% of reported events, not a population-level mortality rate). VeDDRA code: 1187.

By species: Dog (487 reports), Cat (77 reports), Horse (44 reports). By breed: Retriever - Labrador (33), Domestic Shorthair (32), Crossbred Canine/dog (29).

Most co-reported drugs: Oclacitinib Maleate (60 reports), Selamectin (50 reports), Milbemycin Oxime + Spinosad (47 reports), Trilostane (34 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.