Other abnormal test result NOS

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VeDDRA Code: 1221

20,496 adverse event reports referencing this reaction

20,496
Total Reports
3,470
Deaths
1690.0%
Death Rate

Species Most Affected

Dog 17,426
Cat 2,453
Horse 282
Cattle 230
Human 38
Pig 23
Sheep 5
Chicken 5
Goat 5
Lion 3

Breeds Most Affected

Retriever - Labrador 2,238
Domestic Shorthair 1,584
Crossbred Canine/dog 967
Retriever - Golden 816
Shepherd Dog - German 662
Terrier - Yorkshire 569
Chihuahua 565
Shih Tzu 549
Boxer (German Boxer) 472
Beagle 414

Associated Drugs

Milbemycin Oxime + Spinosad 2,738
Milbemycin Oxime + Praziquantel 1,741
Carprofen 1,423
Oclacitinib Maleate 1,363
Afoxolaner 1,208
Ivermectin + Pyrantel As Pamoate Salt 1,163
Trilostane 1,150
Maropitant Citrate 1,110
Imidacloprid + Moxidectin 964
Fluralaner Chew Tablets 800
Lotilaner 763
Spinosad 740
Cyclosporine A 735
Deracoxib 707
Prednisone 668
Cefovecin 589
Moxidectin 534
Tramadol 507
Enrofloxacin 436
Meloxicam 431

Data Summary

Metric Value
Total reports referencing reaction 20,496
Reports with fatal outcome 3,470
Case-fatality rate (reported events) 1690.0%
Species observed 10
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 1221.

Other abnormal test result NOS Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 20,496 adverse event reports that reference Other abnormal test result NOS as a reaction term, including 3,470 reports with a death outcome — a 1690.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 1221, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Other abnormal test result NOS appears most frequently in reports for Dog (17,426 reports), Cat (2,453 reports), Horse (282 reports) — with Dog dominating at 17,426 entries. Within those species, the breeds most often named alongside this reaction are Retriever - Labrador (2,238), Domestic Shorthair (1,584), Crossbred Canine/dog (967). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Other abnormal test result NOS are Milbemycin Oxime + Spinosad (2,738 reports), Milbemycin Oxime + Praziquantel (1,741 reports), Carprofen (1,423 reports), Oclacitinib Maleate (1,363 reports), with Milbemycin Oxime + Spinosad appearing alongside this reaction in 2,738 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial