Reaction profile

The FDA adverse-event record for death by euthanasia

21,034 FDA reports name death by euthanasia, a high-volume reaction in the CVM extract (VeDDRA 981). Plate stamps and neighbourhood peers follow.

#18 of 2,481
by report volume (all reactions)
21,034
reports citing this reaction
99.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Death by euthanasia has 21,034 reports now versus 20,680 in that prior snapshot: 354 more (1.7%).

Report change
+354
Death-coded reports
+354
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Death by euthanasia changes

FDA AER · VeDDRA plate

Code 981 VOL-HIGH

VOL-HIGH · DEATH-HOT · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-HIGH 21,034 reports
  • DEATH-HOT 99.3%
  • TOP-DECILE #18/2481
  • PHOTO-FINISH Not eating
  • SPECIES-DOG Dog · 15,706
  • DRUG-LEAD Bedinvetmab · 2,372
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Not eating (±27 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Death by euthanasia

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Digestive tract disor… · near22748Ataxia · near21626Other abnormal test r… · near21162Death by euthanasia · this r…21034Not eating · near21007Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Death by euthanasia

Death by euthanasia: high death-coded share in the FDA AER plate

Signature read: 20,878 death-coded reports is a heavy tail count for Death by euthanasia in the CVM extract. Report volume is upper-third scale: 21,034 named reports in the openFDA extract. Death-coded share is upper-third: 20,878 of 21,034 reports (99.3% of named reports). Nearest volume peer: Not eating (±27 reports). Lead species Dog (15,706). Lead co-reported drug Bedinvetmab (2,372).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 15,706
Cat 4,174
Horse 453
Cattle 426
Pig 85
Chicken 30
Sheep 18
Fish 16
Rat 14
Rabbit 13

Breeds Most Affected

Domestic Shorthair 2,228
Retriever - Labrador 1,950
Crossbred Canine/dog 1,095
Dog (unknown) 896
Retriever - Golden 712
Shepherd Dog - German 597
Chihuahua 470
Domestic (unspecified) 437
Boxer (German Boxer) 428
Shih Tzu 407

Associated Drugs

Bedinvetmab 2,372
Carprofen 2,023
Maropitant Citrate 1,564
Milbemycin Oxime + Spinosad 1,257
Trilostane 1,199
Gabapentin 1,141
Oclacitinib Maleate 790
Cefovecin 752
Prednisone 730
Afoxolaner 724
Ivermectin + Pyrantel As Pamoate Salt 690
Meloxicam 651
Fluralaner Chew Tablets 634
Moxidectin 560
Enrofloxacin 537
Spinosad 527
Frunevetmab 498
Grapiprant 485
Buprenorphine 454
Famotidine 427

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Death by euthanasia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (21,034 here).

Similar death-coded share

Nearest other reactions by death-coded share (99.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Death by euthanasia (#18 of 2,481 by report volume); death-coded 99.3%. PlainBreed reaction plate · death-coded report count stamp 20,878 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →