Reaction profile

The FDA adverse-event record for death by euthanasia

20,072 FDA adverse-event reports reference death by euthanasia (VeDDRA 981). See the species, breeds, and drugs most associated with it below.

20,072
reports citing this reaction
99.2%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
20,072
Total Reports
19,921
Deaths
99.2%
Death Rate

Species Most Affected

Dog 15,059
Cat 3,908
Horse 429
Cattle 409
Pig 84
Chicken 30
Sheep 16
Fish 16
Rat 14
Turkey 13

Breeds Most Affected

Domestic Shorthair 2,066
Retriever - Labrador 1,850
Crossbred Canine/dog 1,057
Dog (unknown) 866
Retriever - Golden 686
Shepherd Dog - German 569
Chihuahua 450
Domestic (unspecified) 436
Boxer (German Boxer) 412
Shih Tzu 389

Associated Drugs

Bedinvetmab 2,087
Carprofen 1,902
Maropitant Citrate 1,466
Milbemycin Oxime + Spinosad 1,250
Trilostane 1,167
Gabapentin 987
Oclacitinib Maleate 736
Cefovecin 719
Afoxolaner 698
Prednisone 689
Ivermectin + Pyrantel As Pamoate Salt 668
Fluralaner Chew Tablets 634
Meloxicam 629
Moxidectin 532
Spinosad 527
Enrofloxacin 524
Grapiprant 447
Frunevetmab 429
Buprenorphine 418
Deracoxib 416

Death by euthanasia Reaction Insights

20,072 reports name Death by euthanasia; 19,921 recorded a death outcome (99.2% of reported events, not a population-level mortality rate). VeDDRA code: 981.

By species: Dog (15,059 reports), Cat (3,908 reports), Horse (429 reports). By breed: Domestic Shorthair (2,066), Retriever - Labrador (1,850), Crossbred Canine/dog (1,057).

Most co-reported drugs: Bedinvetmab (2,087 reports), Carprofen (1,902 reports), Maropitant Citrate (1,466 reports), Milbemycin Oxime + Spinosad (1,250 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.