Reaction profile

The FDA adverse-event record for ineffective, estrus induction

67 FDA adverse-event reports reference ineffective, estrus induction (VeDDRA 99954). See the species, breeds, and drugs most associated with it below.

67
reports citing this reaction
3.0%
death-coded share
Cattle
most-affected species
Progesterone
most-associated drug
Verify with FDA CVM →
67
Total Reports
2
Deaths
3.0%
Death Rate

Species Most Affected

Cattle 23
Sheep 15
Pig 15
Horse 6
Goat 5
Dog 2
Other Porcine 1

Breeds Most Affected

Cattle (other) 9
Commercial hybrid 8
Crossbred Ovine/sheep 5
Aberdeen Angus 4
Pig (unknown) 4
Sheep (unknown) 4
Southdown 3
Cattle (unspecified) 3
Unknown 3
Goat (unknown) 2

Associated Drugs

Progesterone 19
Cloprostenol 263 Inj Cattle 16
Pregnyl/Gestyl 200/400 15
Dinoprost Tromethamine 8
Cloprostenol Sodium 4
Altrenogest Oily Solution 4
Hcg (Fd) Injectable 2
Cloprostenol 2
Gonadorelin Hydrochloride 1
Gonadorelin Diacetate Tetrahydrate 1
Gonadotrophin, Chorionic + Serum Gonadotropin 1
Fsh Analog 1
Cystorellin 1

INEFFECTIVE, ESTRUS INDUCTION Reaction Insights

67 reports name INEFFECTIVE, ESTRUS INDUCTION; 2 recorded a death outcome (3.0% of reported events, not a population-level mortality rate). VeDDRA code: 99954.

By species: Cattle (23 reports), Sheep (15 reports), Pig (15 reports). By breed: Cattle (other) (9), Commercial hybrid (8), Crossbred Ovine/sheep (5).

Most co-reported drugs: Progesterone (19 reports), Cloprostenol 263 Inj Cattle (16 reports), Pregnyl/Gestyl 200/400 (15 reports), Dinoprost Tromethamine (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.