Reaction profile

The FDA adverse-event record for ineffective, estrus induction

67 FDA adverse-event reports reference ineffective, estrus induction (VeDDRA 99954). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1593 of 2,481
by report volume (all reactions)
67
reports citing this reaction
3.0%
death-coded share
Cattle
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. INEFFECTIVE, ESTRUS INDUCTION has 67 reports now versus 67 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to INEFFECTIVE, ESTRUS INDUCTION changes

FDA AER · VeDDRA plate

Code 99954 VOL-LOW

VOL-LOW · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-CATTLE · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 67 reports
  • DEATH-LOW 3.0%
  • MID-PACK #1593/2481
  • PHOTO-FINISH Application site burn…
  • SPECIES-CATTLE Cattle · 23
  • DRUG-LEAD Progesterone · 19
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site burning sensation (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around INEFFECTIVE, ESTRUS INDUCTION

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Application site burn… · near67Clumsy · near67Fluid from nose · near67INEFFECTIVE, ESTRUS I… · thi…67Irregular pulse · near67Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around INEFFECTIVE, ESTRUS INDUCTION

INEFFECTIVE, ESTRUS INDUCTION: low death-coded share in the FDA AER plate

Signature read: 2 death-coded reports is a thin tail count for INEFFECTIVE, ESTRUS INDUCTION in the CVM extract. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 2 of 67 reports (3.0% of named reports). Nearest volume peer: Application site burning sensation (±0 reports). Lead species Cattle (23). Lead co-reported drug Progesterone (19).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Progesterone appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cattle 23
Sheep 15
Pig 15
Horse 6
Goat 5
Dog 2
Other Porcine 1

Breeds Most Affected

Cattle (other) 9
Commercial hybrid 8
Crossbred Ovine/sheep 5
Aberdeen Angus 4
Pig (unknown) 4
Sheep (unknown) 4
Southdown 3
Cattle (unspecified) 3
Unknown 3
Goat (unknown) 2

Associated Drugs

Progesterone 19
Cloprostenol 263 Inj Cattle 16
Pregnyl/Gestyl 200/400 15
Dinoprost Tromethamine 8
Cloprostenol Sodium 4
Altrenogest Oily Solution 4
Hcg (Fd) Injectable 2
Cloprostenol 2
Gonadorelin Hydrochloride 1
Gonadorelin Diacetate Tetrahydrate 1
Gonadotrophin, Chorionic + Serum Gonadotropin 1
Fsh Analog 1
Cystorellin 1

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for INEFFECTIVE, ESTRUS INDUCTION, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (67 here).

Similar death-coded share

Nearest other reactions by death-coded share (3.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for INEFFECTIVE, ESTRUS INDUCTION (#1593 of 2,481 by report volume); death-coded 3.0%. PlainBreed reaction plate · death-coded report count stamp 2 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →