Reaction profile

The FDA adverse-event record for decreased mean corpuscular volume (mcv)

101 FDA adverse-event reports reference decreased mean corpuscular volume (mcv) (VeDDRA 2855). See the species, breeds, and drugs most associated with it below.

101
reports citing this reaction
25.7%
death-coded share
Dog
most-affected species
Gabapentin
most-associated drug
Verify with FDA CVM →
101
Total Reports
26
Deaths
25.7%
Death Rate

Species Most Affected

Dog 86
Cat 15

Breeds Most Affected

Retriever - Labrador 14
Domestic Shorthair 9
Shepherd Dog - German 8
Crossbred Canine/dog 5
Schnauzer - Miniature 4
Dachshund (unspecified) 3
Bulldog - French 3
Retriever - Golden 3
Poodle (unspecified) 2
Dalmatian 2

Associated Drugs

Gabapentin 17
Enrofloxacin 13
Afoxolaner 13
Carprofen 12
Maropitant Citrate 10
Bedinvetmab 9
Metronidazole 8
Oclacitinib Maleate 8
Milbemycin Oxime + Praziquantel 7
Buprenorphine 7
Dexamethasone Sodium Phosphate 7
Prednisone 7
Milbemycin Oxime + Spinosad 6
Fluralaner 13.64% 12-Week Chew 6
Capromorelin Tartrate 6
Amoxicillin + Clavulanic Acid 6
Ilunocitinib 6
Trilostane 5
Fenbendazole 5
Metoclopramide 5

Decreased mean corpuscular volume (MCV) Reaction Insights

101 reports name Decreased mean corpuscular volume (MCV); 26 recorded a death outcome (25.7% of reported events, not a population-level mortality rate). VeDDRA code: 2855.

By species: Dog (86 reports), Cat (15 reports). By breed: Retriever - Labrador (14), Domestic Shorthair (9), Shepherd Dog - German (8).

Most co-reported drugs: Gabapentin (17 reports), Enrofloxacin (13 reports), Afoxolaner (13 reports), Carprofen (12 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.