Reaction profile

The FDA adverse-event record for loss of consciousness

516 FDA adverse-event reports reference loss of consciousness (VeDDRA 667). See the species, breeds, and drugs most associated with it below.

516
reports citing this reaction
32.4%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
516
Total Reports
167
Deaths
32.4%
Death Rate

Species Most Affected

Dog 393
Cat 102
Human 9
Horse 3
Cattle 3
Goat 2
Pig 2
Other Deer 1
Turtle 1

Breeds Most Affected

Domestic (unspecified) 54
Crossbred Canine/dog 47
Retriever - Labrador 31
Chihuahua 26
Domestic Shorthair 20
Boxer (German Boxer) 17
Retriever - Golden 17
Shih Tzu 14
Maltese 14
Shepherd Dog - Australian 13

Associated Drugs

Milbemycin Oxime + Spinosad 44
Cefovecin Sodium 34
Spinosad 33
Afoxolaner 33
Fluralaner Chew Tablets 32
Ivermectin 31
Carprofen 18
Maropitant 16
Moxidectin 15
Maropitant Citrate 14
Selamectin 13
Fluralaner 13.64% 12-Week Chew 13
Pyrantel Pamoate;Sarolaner 12
Melarsomine Dihydrochloride 11
Ivermectin + Pyrantel As Pamoate Salt 11
Oclacitinib Maleate 10
Dexmedetomidine Hydrochloride 9
Firocoxib 9
Milbemycin Oxime + Praziquantel 9
Prednisone 8

Loss of consciousness Reaction Insights

516 reports name Loss of consciousness; 167 recorded a death outcome (32.4% of reported events, not a population-level mortality rate). VeDDRA code: 667.

By species: Dog (393 reports), Cat (102 reports), Human (9 reports). By breed: Domestic (unspecified) (54), Crossbred Canine/dog (47), Retriever - Labrador (31).

Most co-reported drugs: Milbemycin Oxime + Spinosad (44 reports), Cefovecin Sodium (34 reports), Spinosad (33 reports), Afoxolaner (33 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.