Reaction profile

The FDA adverse-event record for cholangiohepatitis

129 FDA adverse-event reports reference cholangiohepatitis (VeDDRA 476). See the species, breeds, and drugs most associated with it below.

129
reports citing this reaction
33.3%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
129
Total Reports
43
Deaths
33.3%
Death Rate

Species Most Affected

Dog 88
Cat 38
Horse 2
Cattle 1

Breeds Most Affected

Domestic Shorthair 31
Crossbred Canine/dog 9
Retriever - Labrador 9
Shih Tzu 5
Chihuahua 4
Sheepdog - Shetland 3
Shepherd Dog - German 3
Dachshund (unspecified) 3
Retriever - Golden 3
Pug 3

Associated Drugs

Maropitant Citrate 14
Carprofen 13
Trilostane 11
Spinosad 10
Enrofloxacin 10
Milbemycin Oxime + Spinosad 9
Prednisone 7
Famotidine 7
Cefovecin 7
Deracoxib 7
Afoxolaner 7
Grapiprant 7
Metronidazole 6
Tramadol 6
Moxidectin 6
Gabapentin 6
Frunevetmab 6
Fluralaner 5
Doxycycline 4
Cyclosporine A 4

Cholangiohepatitis Reaction Insights

129 reports name Cholangiohepatitis; 43 recorded a death outcome (33.3% of reported events, not a population-level mortality rate). VeDDRA code: 476.

By species: Dog (88 reports), Cat (38 reports), Horse (2 reports). By breed: Domestic Shorthair (31), Crossbred Canine/dog (9), Retriever - Labrador (9).

Most co-reported drugs: Maropitant Citrate (14 reports), Carprofen (13 reports), Trilostane (11 reports), Spinosad (10 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.