Reaction profile

The FDA adverse-event record for abnormal serum protein nos

135 FDA adverse-event reports reference abnormal serum protein nos (VeDDRA 2220). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1238 of 2,481
by report volume (all reactions)
135
reports citing this reaction
15.6%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Abnormal serum protein NOS has 135 reports now versus 132 in that prior snapshot: 3 more (2.3%).

Report change
+3
Death-coded reports
+2
Death-coded share
+1.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Abnormal serum protein NOS changes

FDA AER · VeDDRA plate

Code 2220 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 135 reports
  • DEATH-ELEV 15.6%
  • MID-PACK #1238/2481
  • PHOTO-FINISH Cholangiohepatitis
  • SPECIES-DOG Dog · 84
  • DRUG-LEAD Bexagliflozin · 13
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Cholangiohepatitis (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Abnormal serum protein NOS

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Abnormal serum protei… · thi…135Cholangiohepatitis · near135Decreased mean corpus… · near135Laminitis · near135Other coagulation abn… · near135Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Abnormal serum protein NOS

What the FDA AER plate says about Abnormal serum protein NOS

Signature read: 21 death-coded reports is the most distinctive absolute-outcome stamp on Abnormal serum protein NOS. Report volume sits in the middle third of the reaction corpus. 21 of 135 reports were death-coded (15.6% of named reports, not a population mortality rate). Nearest volume peer: Cholangiohepatitis (±0 reports). Lead species Dog (84). Lead co-reported drug Bexagliflozin (13).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Bexagliflozin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 84
Cat 30
Horse 21

Breeds Most Affected

Domestic Shorthair 19
Retriever - Labrador 13
Crossbred Canine/dog 11
Quarter Horse 7
Terrier - Yorkshire 6
Domestic Mediumhair 4
Maltese 3
Shepherd Dog - German 3
Terrier (unspecified) 3
Chihuahua 2

Associated Drugs

Bexagliflozin 13
Bedinvetmab 13
Maropitant Citrate 12
Gabapentin 11
Milbemycin Oxime + Spinosad 9
Oclacitinib Maleate 8
Insulin Injectable Vial 8
Hyaluronate Sodium 7
Carprofen 6
Rabies Vaccine 6
Cyclosporine 6
Robenacoxib 5
Milbemycin Oxime + Praziquantel 5
Fluralaner 5
Trilostane 5
Grapiprant 5
Afoxolaner 5
Ivermectin + Pyrantel As Pamoate Salt 4
Ketamine 4
Meloxicam 4

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Abnormal serum protein NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (15.6% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Abnormal serum protein NOS (#1238 of 2,481 by report volume); death-coded 15.6%. PlainBreed reaction plate · death-coded report count stamp 21 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →