Reaction profile

The FDA adverse-event record for abnormal serum protein nos

128 FDA adverse-event reports reference abnormal serum protein nos (VeDDRA 2220). See the species, breeds, and drugs most associated with it below.

128
reports citing this reaction
14.1%
death-coded share
Dog
most-affected species
Bexagliflozin
most-associated drug
Verify with FDA CVM →
128
Total Reports
18
Deaths
14.1%
Death Rate

Species Most Affected

Dog 80
Cat 27
Horse 21

Breeds Most Affected

Domestic Shorthair 17
Retriever - Labrador 12
Crossbred Canine/dog 11
Quarter Horse 7
Terrier - Yorkshire 6
Maltese 3
Domestic Mediumhair 3
Chihuahua 2
Shepherd Dog - German 2
Bichon Frise 2

Associated Drugs

Bexagliflozin 12
Maropitant Citrate 11
Bedinvetmab 11
Milbemycin Oxime + Spinosad 9
Gabapentin 9
Insulin Injectable Vial 8
Hyaluronate Sodium 7
Oclacitinib Maleate 6
Rabies Vaccine 6
Cyclosporine 6
Robenacoxib 5
Milbemycin Oxime + Praziquantel 5
Fluralaner 5
Trilostane 5
Grapiprant 5
Carprofen 4
Ketamine 4
Polysulfated Glycosaminoglycan 4
Prednisone 4
Firocoxib 4

Abnormal serum protein NOS Reaction Insights

128 reports name Abnormal serum protein NOS; 18 recorded a death outcome (14.1% of reported events, not a population-level mortality rate). VeDDRA code: 2220.

By species: Dog (80 reports), Cat (27 reports), Horse (21 reports). By breed: Domestic Shorthair (17), Retriever - Labrador (12), Crossbred Canine/dog (11).

Most co-reported drugs: Bexagliflozin (12 reports), Maropitant Citrate (11 reports), Bedinvetmab (11 reports), Milbemycin Oxime + Spinosad (9 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.