Reaction profile

The FDA adverse-event record for cardiomyopathy

265 FDA adverse-event reports reference cardiomyopathy (VeDDRA 205). See the species, breeds, and drugs most associated with it below.

265
reports citing this reaction
63.0%
death-coded share
Dog
most-affected species
Spinosad
most-associated drug
Verify with FDA CVM →
265
Total Reports
167
Deaths
63.0%
Death Rate

Species Most Affected

Dog 142
Cat 110
Cattle 7
Chicken 4
Turkey 1
Deer 1

Breeds Most Affected

Domestic Shorthair 68
Doberman Pinscher 16
Domestic Longhair 15
Boxer (German Boxer) 14
Retriever - Golden 7
Retriever - Labrador 7
Chihuahua 5
Crossbred Canine/dog 5
Maltese 5
Spaniel - King Charles Cavalier 5

Associated Drugs

Spinosad 34
Milbemycin Oxime + Spinosad 28
Maropitant Citrate 24
Buprenorphine 19
Cefovecin 17
Gabapentin 14
Cyclosporine 12
Trilostane 11
Afoxolaner 11
Robenacoxib 11
Cefovecin Sodium 10
Isoflurane 10
Fluralaner Spot-On Solution 10
Fluralaner Chew Tablets 9
Enrofloxacin 8
Moxidectin 8
Ivermectin + Pyrantel As Pamoate Salt 8
Oclacitinib Maleate 8
Pimobendan 8
Monensin Sodium 7

Cardiomyopathy Reaction Insights

265 reports name Cardiomyopathy; 167 recorded a death outcome (63.0% of reported events, not a population-level mortality rate). VeDDRA code: 205.

By species: Dog (142 reports), Cat (110 reports), Cattle (7 reports). By breed: Domestic Shorthair (68), Doberman Pinscher (16), Domestic Longhair (15).

Most co-reported drugs: Spinosad (34 reports), Milbemycin Oxime + Spinosad (28 reports), Maropitant Citrate (24 reports), Buprenorphine (19 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.