Reaction profile

The FDA adverse-event record for pleural effusion

654 FDA adverse-event reports reference pleural effusion (VeDDRA 1184). See the species, breeds, and drugs most associated with it below.

654
reports citing this reaction
63.9%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
654
Total Reports
418
Deaths
63.9%
Death Rate

Species Most Affected

Dog 377
Cat 237
Cattle 26
Horse 11
Pig 2
Tiger 1

Breeds Most Affected

Domestic Shorthair 111
Retriever - Labrador 55
Domestic (unspecified) 33
Domestic Longhair 20
Crossbred Canine/dog 19
Maltese 17
Chihuahua 16
Siamese 13
Domestic Mediumhair 13
Shepherd Dog - Australian 12

Associated Drugs

Maropitant Citrate 92
Carprofen 58
Cefovecin 52
Oclacitinib Maleate 38
Milbemycin Oxime + Spinosad 36
Furosemide 33
Moxidectin 32
Enrofloxacin 31
Fluralaner Chew Tablets 29
Buprenorphine 28
Gabapentin 28
Frunevetmab 28
Prednisone 27
Cefovecin Sodium 26
Famotidine 26
Mirtazapine 25
Spinosad 24
Bedinvetmab 24
Butorphanol 23
Meloxicam 22

Pleural effusion Reaction Insights

654 reports name Pleural effusion; 418 recorded a death outcome (63.9% of reported events, not a population-level mortality rate). VeDDRA code: 1184.

By species: Dog (377 reports), Cat (237 reports), Cattle (26 reports). By breed: Domestic Shorthair (111), Retriever - Labrador (55), Domestic (unspecified) (33).

Most co-reported drugs: Maropitant Citrate (92 reports), Carprofen (58 reports), Cefovecin (52 reports), Oclacitinib Maleate (38 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.