Reaction profile

The FDA adverse-event record for cognitive disorder nos

260 FDA adverse-event reports reference cognitive disorder nos (VeDDRA 1382). See the species, breeds, and drugs most associated with it below.

260
reports citing this reaction
27.3%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
260
Total Reports
71
Deaths
27.3%
Death Rate

Species Most Affected

Dog 246
Cat 13
Human 1

Breeds Most Affected

Retriever - Labrador 24
Dog (unknown) 19
Crossbred Canine/dog 14
Chihuahua 14
Beagle 10
Terrier - Yorkshire 9
Terrier - Jack Russell 8
Shepherd Dog - Australian 8
Shepherd Dog - German 8
Domestic Shorthair 7

Associated Drugs

Bedinvetmab 118
Trilostane 77
Carprofen 30
Gabapentin 28
Milbemycin Oxime + Spinosad 10
Pimobendan 10
Grapiprant 9
Pyrantel Pamoate;Sarolaner 9
Galliprant 9
Enalapril 8
Trazodone 8
Fluralaner 13.64% 12-Week Chew 7
Denamarin 6
Afoxolaner 5
Prednisone 5
Metronidazole 5
Frunevetmab 5
Keppra 5
Alprazolam 4
Buprenorphine 4

Cognitive disorder NOS Reaction Insights

260 reports name Cognitive disorder NOS; 71 recorded a death outcome (27.3% of reported events, not a population-level mortality rate). VeDDRA code: 1382.

By species: Dog (246 reports), Cat (13 reports), Human (1 reports). By breed: Retriever - Labrador (24), Dog (unknown) (19), Crossbred Canine/dog (14).

Most co-reported drugs: Bedinvetmab (118 reports), Trilostane (77 reports), Carprofen (30 reports), Gabapentin (28 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.