Reaction profile

The FDA adverse-event record for peeling skin

277 FDA adverse-event reports reference peeling skin (VeDDRA 944). See the species, breeds, and drugs most associated with it below.

277
reports citing this reaction
9.7%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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277
Total Reports
27
Deaths
9.7%
Death Rate

Species Most Affected

Dog 172
Cat 60
Human 22
Horse 16
Cattle 6
Fish 1

Breeds Most Affected

Domestic Shorthair 37
Unknown 26
Crossbred Canine/dog 15
Chihuahua 13
Retriever - Labrador 10
Domestic (unspecified) 9
Terrier - Boston 6
Retriever - Golden 6
Quarter Horse 5
Dog (unknown) 5

Associated Drugs

Milbemycin Oxime + Spinosad 21
Trilostane 19
Selamectin 16
Afoxolaner 15
Oclacitinib Maleate 15
Prednisone 13
Carprofen 10
Cefovecin 10
Cefovecin Sodium 8
Buprenorphine 8
Cyclosporine 7
Fluralaner Chew Tablets 7
Ivermectin + Pyrantel As Pamoate Salt 7
Emodepside + Praziquantel 6
Imidacloprid + Moxidectin 6
Moxidectin 6
Mirtazapine 6
Ivermectin(1.55%)/Praziquantel(7.75%) Paste 6
Cephalexin 6
Sarolaner 6

Peeling skin Reaction Insights

277 reports name Peeling skin; 27 recorded a death outcome (9.7% of reported events, not a population-level mortality rate). VeDDRA code: 944.

By species: Dog (172 reports), Cat (60 reports), Human (22 reports). By breed: Domestic Shorthair (37), Unknown (26), Crossbred Canine/dog (15).

Most co-reported drugs: Milbemycin Oxime + Spinosad (21 reports), Trilostane (19 reports), Selamectin (16 reports), Afoxolaner (15 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.