Reaction profile
The FDA adverse-event record for liver failure
648 FDA reports name liver failure, a high-volume reaction in the CVM extract (VeDDRA 1109). Plate stamps and neighbourhood peers follow.
- #540 of 2,481
- by report volume (all reactions)
- 648
- reports citing this reaction
- 63.3%
- death-coded share
- Dog
- most-affected species
Release-over-release change
What changed in the latest FDA data snapshot
PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Liver failure has 648 reports now versus 635 in that prior snapshot: 13 more (2.0%).
- Report change
- +13
- Death-coded reports
- +9
- Death-coded share
- +0.1 pts
This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.
Subscribe to Liver failure changesFDA AER · VeDDRA plate
Code 1109 VOL-MID
VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL
- VOL-MID 648 reports
- DEATH-HOT 63.3%
- UPPER-Q #540/2481
- PHOTO-FINISH Patient instructions…
- SPECIES-DOG Dog · 565
- DRUG-LEAD Carprofen · 171
- DESK-WIDE 20 breeds
- BOOK-FULL 8/8 fields
Nearest volume peer: Patient instructions for use on label confusing (±1 reports)
Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.
High-volume neighbourhood around Liver failure
Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.
Liver failure: high death-coded share in the FDA AER plate
Signature read: 410 death-coded reports is a heavy tail count for Liver failure in the CVM extract. Report volume is upper-third scale: 648 named reports in the openFDA extract. Death-coded share is upper-third: 410 of 648 reports (63.3% of named reports). Nearest volume peer: Patient instructions for use on label confusing (±1 reports). Lead species Dog (565). Lead co-reported drug Carprofen (171).
Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.
Species Most Affected
Breeds Most Affected
Associated Drugs
Nationwide reactions with similar profiles
Two openFDA-derived peer sets for Liver failure, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).
Similar report volume
Nearest other reactions by FDA report count (648 here).
Similar death-coded share
Nearest other reactions by death-coded share (63.3% here), distinct from the volume row.
What to do with this reaction
- Compare Liver failure's report profile against similar reactions nationwide. See similar reactions
- Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
- Browse the full reaction directory to compare report counts across reaction types. All reactions
A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.
Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025
Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →