Reaction profile

The FDA adverse-event record for splenic neoplasm

385 FDA adverse-event reports reference splenic neoplasm (VeDDRA 1977). See the species, breeds, and drugs most associated with it below.

385
reports citing this reaction
62.3%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
385
Total Reports
240
Deaths
62.3%
Death Rate

Species Most Affected

Dog 379
Cat 5
Horse 1

Breeds Most Affected

Retriever - Labrador 57
Shepherd Dog - German 29
Crossbred Canine/dog 28
Retriever - Golden 27
Beagle 17
Dog (unknown) 13
Rottweiler 11
Collie - Border 8
Chihuahua 7
Shih Tzu 6

Associated Drugs

Oclacitinib Maleate 62
Carprofen 53
Milbemycin Oxime + Spinosad 47
Trilostane 30
Afoxolaner 28
Fluralaner Chew Tablets 24
Maropitant Citrate 22
Ivermectin + Pyrantel As Pamoate Salt 18
Spinosad 15
Tramadol 13
Cyclosporine 12
Meloxicam 12
Moxidectin 12
Polysulfated Glycosaminoglycan 12
Grapiprant 12
Deracoxib 11
Milbemycin Oxime + Praziquantel 10
Firocoxib 9
Prednisone 9
Gabapentin 8

Splenic neoplasm Reaction Insights

385 reports name Splenic neoplasm; 240 recorded a death outcome (62.3% of reported events, not a population-level mortality rate). VeDDRA code: 1977.

By species: Dog (379 reports), Cat (5 reports), Horse (1 reports). By breed: Retriever - Labrador (57), Shepherd Dog - German (29), Crossbred Canine/dog (28).

Most co-reported drugs: Oclacitinib Maleate (62 reports), Carprofen (53 reports), Milbemycin Oxime + Spinosad (47 reports), Trilostane (30 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.