Reaction profile

The FDA adverse-event record for adipsia

3,781 FDA adverse-event reports reference adipsia (VeDDRA 542). See the species, breeds, and drugs most associated with it below.

3,781
reports citing this reaction
19.5%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
3,781
Total Reports
739
Deaths
19.5%
Death Rate

Species Most Affected

Dog 2,668
Cat 1,049
Horse 26
Cattle 10
Rabbit 6
Chicken 4
Guinea Pig 3
Ferret 3
Goat 3
Pig 3

Breeds Most Affected

Domestic Shorthair 548
Retriever - Labrador 236
Crossbred Canine/dog 216
Chihuahua 201
Terrier - Yorkshire 122
Domestic (unspecified) 118
Boxer (German Boxer) 115
Shih Tzu 111
Retriever - Golden 95
Domestic Longhair 92

Associated Drugs

Milbemycin Oxime + Spinosad 541
Carprofen 299
Maropitant Citrate 264
Cefovecin 235
Spinosad 223
Imidacloprid + Moxidectin 202
Afoxolaner 174
Selamectin 173
Meloxicam 147
Moxidectin 109
Pyrantel Pamoate;Sarolaner 98
Ivermectin + Pyrantel As Pamoate Salt 88
Fluralaner Chew Tablets 84
Emodepside + Praziquantel 83
Buprenorphine 83
Sarolaner 77
Prednisone 76
Enrofloxacin 69
Oclacitinib Maleate 69
Trilostane 66

Adipsia Reaction Insights

3,781 reports name Adipsia; 739 recorded a death outcome (19.5% of reported events, not a population-level mortality rate). VeDDRA code: 542.

By species: Dog (2,668 reports), Cat (1,049 reports), Horse (26 reports). By breed: Domestic Shorthair (548), Retriever - Labrador (236), Crossbred Canine/dog (216).

Most co-reported drugs: Milbemycin Oxime + Spinosad (541 reports), Carprofen (299 reports), Maropitant Citrate (264 reports), Cefovecin (235 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.