Reaction profile

The FDA adverse-event record for adipsia

3,830 FDA reports name adipsia, a high-volume reaction in the CVM extract (VeDDRA 542). Plate stamps and neighbourhood peers follow.

#124 of 2,481
by report volume (all reactions)
3,830
reports citing this reaction
19.6%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Adipsia has 3,830 reports now versus 3,805 in that prior snapshot: 25 more (0.7%).

Report change
+25
Death-coded reports
+4
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Adipsia changes

FDA AER · VeDDRA plate

Code 542 VOL-MID

VOL-MID · DEATH-ELEV · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 3,830 reports
  • DEATH-ELEV 19.6%
  • TOP-DECILE #124/2481
  • PHOTO-FINISH Odor, Abnormal
  • SPECIES-DOG Dog · 2,699
  • DRUG-LEAD Milbemycin Oxime… · 542
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Odor, Abnormal (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Adipsia

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Lameness · near3919Proteinuria · near3907Lack of efficacy (bac… · near3861Adipsia · this reaction3830Odor, Abnormal · near3829Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Adipsia

What the FDA AER plate says about Adipsia

Signature read: 752 death-coded reports is a heavy tail count for Adipsia in the CVM extract. Report volume is upper-third scale: 3,830 named reports in the openFDA extract. 752 of 3,830 reports were death-coded (19.6% of named reports, not a population mortality rate). Nearest volume peer: Odor, Abnormal (±1 reports). Lead species Dog (2,699). Lead co-reported drug Milbemycin Oxime + Spinosad (542).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 2,699
Cat 1,066
Horse 26
Cattle 11
Rabbit 6
Chicken 4
Guinea Pig 3
Ferret 3
Goat 3
Pig 3

Breeds Most Affected

Domestic Shorthair 561
Retriever - Labrador 238
Crossbred Canine/dog 218
Chihuahua 201
Terrier - Yorkshire 122
Domestic (unspecified) 119
Boxer (German Boxer) 116
Shih Tzu 113
Retriever - Golden 96
Domestic Longhair 92

Associated Drugs

Milbemycin Oxime + Spinosad 542
Carprofen 301
Maropitant Citrate 276
Cefovecin 238
Spinosad 223
Imidacloprid + Moxidectin 202
Afoxolaner 176
Selamectin 173
Meloxicam 148
Moxidectin 111
Pyrantel Pamoate;Sarolaner 99
Ivermectin + Pyrantel As Pamoate Salt 88
Buprenorphine 86
Fluralaner Chew Tablets 84
Emodepside + Praziquantel 83
Prednisone 78
Sarolaner 78
Oclacitinib Maleate 71
Enrofloxacin 70
Trilostane 66

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Adipsia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (3,830 here).

Similar death-coded share

Nearest other reactions by death-coded share (19.6% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Adipsia (#124 of 2,481 by report volume); death-coded 19.6%. PlainBreed reaction plate · death-coded report count stamp 752 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →