Reaction profile

The FDA adverse-event record for proteinuria

3,631 FDA adverse-event reports reference proteinuria (VeDDRA 1961). See the species, breeds, and drugs most associated with it below.

3,631
reports citing this reaction
17.7%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
3,631
Total Reports
641
Deaths
17.7%
Death Rate

Species Most Affected

Dog 3,068
Cat 554
Horse 7
Human 1
Cattle 1

Breeds Most Affected

Retriever - Labrador 460
Domestic Shorthair 336
Crossbred Canine/dog 220
Retriever - Golden 146
Terrier - Yorkshire 113
Shih Tzu 94
Beagle 92
Chihuahua 89
Maltese 83
Boxer (German Boxer) 81

Associated Drugs

Trilostane 764
Carprofen 487
Bedinvetmab 351
Oclacitinib Maleate 330
Maropitant Citrate 259
Gabapentin 183
Milbemycin Oxime + Spinosad 181
Afoxolaner 145
Meloxicam 142
Fluralaner Chew Tablets 117
Prednisone 110
Cefovecin 109
Grapiprant 106
Spinosad 88
Famotidine 88
Cyclosporine 79
Ivermectin + Pyrantel As Pamoate Salt 79
Deracoxib 75
Velagliflozin Proline Monohydrate 74
Bexagliflozin 70

Proteinuria Reaction Insights

3,631 reports name Proteinuria; 641 recorded a death outcome (17.7% of reported events, not a population-level mortality rate). VeDDRA code: 1961.

By species: Dog (3,068 reports), Cat (554 reports), Horse (7 reports). By breed: Retriever - Labrador (460), Domestic Shorthair (336), Crossbred Canine/dog (220).

Most co-reported drugs: Trilostane (764 reports), Carprofen (487 reports), Bedinvetmab (351 reports), Oclacitinib Maleate (330 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.