Reaction profile

The FDA adverse-event record for lameness

3,919 FDA reports name lameness, a high-volume reaction in the CVM extract (VeDDRA 615). Plate stamps and neighbourhood peers follow.

#121 of 2,481
by report volume (all reactions)
3,919
reports citing this reaction
17.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lameness has 3,919 reports now versus 3,845 in that prior snapshot: 74 more (1.9%).

Report change
+74
Death-coded reports
+11
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lameness changes

FDA AER · VeDDRA plate

Code 615 VOL-MID

VOL-MID · DEATH-ELEV · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 3,919 reports
  • DEATH-ELEV 17.3%
  • TOP-DECILE #121/2481
  • PHOTO-FINISH Proteinuria
  • SPECIES-DOG Dog · 2,920
  • DRUG-LEAD Bedinvetmab · 520
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Proteinuria (±12 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Lameness

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Injection site pain · near3968Drug dose omission · near3948Lameness · this reaction3919Proteinuria · near3907Lack of efficacy (bac… · near3861Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Lameness

What the FDA AER plate says about Lameness

Signature read: 677 death-coded reports is a heavy tail count for Lameness in the CVM extract. Report volume is upper-third scale: 3,919 named reports in the openFDA extract. 677 of 3,919 reports were death-coded (17.3% of named reports, not a population mortality rate). Nearest volume peer: Proteinuria (±12 reports). Lead species Dog (2,920). Lead co-reported drug Bedinvetmab (520).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Bedinvetmab appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 2,920
Cat 367
Horse 297
Cattle 217
Pig 77
Chicken 14
Turkey 7
Unknown 5
Sheep 5
Human 2

Breeds Most Affected

Retriever - Labrador 454
Crossbred Canine/dog 239
Domestic Shorthair 182
Retriever - Golden 159
Shepherd Dog - German 137
Dog (unknown) 119
Boxer (German Boxer) 95
Chihuahua 67
Pit Bull 66
Terrier - Bull - American Pit 66

Associated Drugs

Bedinvetmab 520
Carprofen 425
Gabapentin 311
Milbemycin Oxime + Spinosad 210
Oclacitinib Maleate 184
Afoxolaner 166
Prednisone 159
Moxidectin 156
Tigilanol Tiglate 153
Maropitant Citrate 139
Frunevetmab 119
Fluralaner Chew Tablets 107
Trilostane 94
Enrofloxacin 91
Hyaluronate Sodium 88
Polysulfated Glycosaminoglycan 88
Tramadol 88
Toceranib Phosphate 82
Grapiprant 79
Lotilaner 79

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Lameness, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (17.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lameness (#121 of 2,481 by report volume); death-coded 17.3%. PlainBreed reaction plate · death-coded report count stamp 677 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →