Reaction profile

The FDA adverse-event record for lack of efficacy (bacteria) - anaplasma

2,913 FDA adverse-event reports reference lack of efficacy (bacteria) - anaplasma (VeDDRA 2990). See the species, breeds, and drugs most associated with it below.

2,913
reports citing this reaction
0.6%
death-coded share
Dog
most-affected species
Pyrantel Pamoate;Sarolaner
most-associated drug
Verify with FDA CVM →
2,913
Total Reports
18
Deaths
0.6%
Death Rate

Species Most Affected

Dog 2,899
Cat 12
Horse 2

Breeds Most Affected

Retriever - Labrador 382
Crossbred Canine/dog 298
Retriever - Golden 287
Dog (unknown) 238
Shepherd Dog - German 135
Shepherd Dog - Australian 120
Mountain Dog - Bernese 65
Terrier (unspecified) 65
Siberian Husky 63
Shih Tzu 60

Associated Drugs

Pyrantel Pamoate;Sarolaner 1,296
Afoxolaner 681
Fluralaner 13.64% 12-Week Chew 550
Lotilaner 138
Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 113
Sarolaner 106
Recombitek Lyme - 2126.R0 82
Fluralaner 5.46% 1-Month Chew 76
Milbemycin Oxime + Praziquantel 71
Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet 62
Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet 60
Ivermectin + Pyrantel As Pamoate Salt 38
Afoxolaner 18.75Mg / Moxidectin 90Mcg / Pyrantel 37.5Mg Chewable Tablet 30
Canine B Burgdorferi *2 Alu Kb 29
Afoxolaner 37.5Mg / Moxidectin 180Mcg / Pyrantel 75Mg Chewable Tablet 24
Fluralaner Spot-On Solution 22
Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 21
Lyme Vaccine 18
Borrelia Burgdorferi Bacterin 16
Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Borrelia Burgdorferi Bacterin-Lepto Cani-Grippo-Ictero-Pomona Bacterial Extract 16

Lack of efficacy (bacteria) - Anaplasma Reaction Insights

2,913 reports name Lack of efficacy (bacteria) - Anaplasma; 18 recorded a death outcome (0.6% of reported events, not a population-level mortality rate). VeDDRA code: 2990.

By species: Dog (2,899 reports), Cat (12 reports), Horse (2 reports). By breed: Retriever - Labrador (382), Crossbred Canine/dog (298), Retriever - Golden (287).

Most co-reported drugs: Pyrantel Pamoate;Sarolaner (1,296 reports), Afoxolaner (681 reports), Fluralaner 13.64% 12-Week Chew (550 reports), Lotilaner (138 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.