Reaction profile

The FDA adverse-event record for odor, abnormal

3,829 FDA reports name odor, abnormal, a high-volume reaction in the CVM extract (VeDDRA 99018). Plate stamps and neighbourhood peers follow.

#125 of 2,481
by report volume (all reactions)
3,829
reports citing this reaction
0.7%
death-coded share
Unknown
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Odor, Abnormal has 3,829 reports now versus 3,783 in that prior snapshot: 46 more (1.2%).

Report change
+46
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Odor, Abnormal changes

FDA AER · VeDDRA plate

Code 99018 VOL-MID

VOL-MID · DEATH-RARE · TOP-DECILE · PHOTO-FINISH · SPECIES-UNKNOWN · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 3,829 reports
  • DEATH-RARE 0.7%
  • TOP-DECILE #125/2481
  • PHOTO-FINISH Adipsia
  • SPECIES-UNKNOWN Unknown · 2,950
  • DRUG-LEAD Milbemycin Oxime… · 1,527
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Adipsia (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Odor, Abnormal

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Lameness · near3919Proteinuria · near3907Lack of efficacy (bac… · near3861Adipsia · near3830Odor, Abnormal · this reacti…3829Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Odor, Abnormal

Odor, Abnormal: low death-coded share in the FDA AER plate

Signature read: 3,829 reports place Odor, Abnormal in the upper third of FDA AER volume (#125 of 2,481). Report volume is upper-third scale: 3,829 named reports in the openFDA extract. Death-coded share is lower-third: 27 of 3,829 reports (0.7% of named reports). Nearest volume peer: Adipsia (±1 reports). Lead species Unknown (2,950). Lead co-reported drug Milbemycin Oxime + Spinosad (1,527).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Unknown 2,950
Dog 624
Cat 183
Human 57
Horse 6
Cattle 2
Goat 2
Rat 1
Monkey 1
Mouse 1

Breeds Most Affected

Unknown 3,011
Dog (unknown) 72
Retriever - Labrador 71
Domestic Shorthair 71
Crossbred Canine/dog 36
Retriever - Golden 31
Chihuahua 29
Cat (other) 29
Cat (unknown) 26
Shih Tzu 20

Associated Drugs

Milbemycin Oxime + Spinosad 1,527
Spinosad 677
Selamectin 332
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 118
Selamectin;Sarolaner 115
Imidacloprid + Moxidectin 113
Carprofen 100
Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate 79
Amoxicillin Trihydrate;Clavulanate Potassium ( K-Clavulanate) 67
Fenbendazol Suspension 48
Cyclosporine 43
Cyclosporine A 36
Fluralaner 13.64% 12-Week Chew 35
Meloxicam 30
Ivermectin + Pyrantel As Pamoate Salt 22
Afoxolaner 21
Pimobendan 20
Milbemycin Oxime + Praziquantel 20
Amoxicillin, Clavulanate 19
Maropitant Citrate 19

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Odor, Abnormal, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (3,829 here).

Similar death-coded share

Nearest other reactions by death-coded share (0.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Odor, Abnormal (#125 of 2,481 by report volume); death-coded 0.7%. PlainBreed reaction plate · report volume stamp 3,829 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →