Reaction profile

The FDA adverse-event record for odor, abnormal

3,716 FDA adverse-event reports reference odor, abnormal (VeDDRA 99018). See the species, breeds, and drugs most associated with it below.

3,716
reports citing this reaction
0.7%
death-coded share
Unknown
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
3,716
Total Reports
25
Deaths
0.7%
Death Rate

Species Most Affected

Unknown 2,874
Dog 597
Cat 177
Human 54
Horse 6
Cattle 2
Rat 1
Goat 1
Monkey 1
Mouse 1

Breeds Most Affected

Unknown 2,932
Retriever - Labrador 70
Dog (unknown) 68
Domestic Shorthair 68
Crossbred Canine/dog 36
Retriever - Golden 31
Chihuahua 29
Cat (other) 29
Cat (unknown) 24
Shih Tzu 20

Associated Drugs

Milbemycin Oxime + Spinosad 1,524
Spinosad 676
Selamectin 324
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 117
Imidacloprid + Moxidectin 106
Selamectin;Sarolaner 99
Carprofen 98
Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate 79
Amoxicillin Trihydrate;Clavulanate Potassium ( K-Clavulanate) 65
Cyclosporine 40
Cyclosporine A 36
Fluralaner 13.64% 12-Week Chew 35
Meloxicam 30
Ivermectin + Pyrantel As Pamoate Salt 21
Afoxolaner 21
Pimobendan 19
Amoxicillin, Clavulanate 19
Phenylpropanolamine Hcl 18
Fluralaner Spot-On Solution 18
Clindamycin Hydrochloride 17

Odor, Abnormal Reaction Insights

3,716 reports name Odor, Abnormal; 25 recorded a death outcome (0.7% of reported events, not a population-level mortality rate). VeDDRA code: 99018.

By species: Unknown (2,874 reports), Dog (597 reports), Cat (177 reports). By breed: Unknown (2,932), Retriever - Labrador (70), Dog (unknown) (68).

Most co-reported drugs: Milbemycin Oxime + Spinosad (1,524 reports), Spinosad (676 reports), Selamectin (324 reports), Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (117 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.