Decreased heart rate
VeDDRA Code: 189
390 adverse event reports referencing this reaction
390
Total Reports
82
Deaths
2100.0%
Death Rate
Species Most Affected
Dog 303
Cat 75
Human 6
Horse 3
Chinchilla 1
Mouse 1
Rabbit 1
Breeds Most Affected
Domestic Shorthair 44
Chihuahua 29
Retriever - Labrador 22
Dog (unknown) 19
Shih Tzu 16
Shepherd Dog - German 13
Maltese 11
Crossbred Canine/dog 11
Terrier - Yorkshire 11
Unknown 11
Associated Drugs
Isoflurane 56
Dexmedetomidine Hydrochloride 53
Maropitant Citrate 41
Propofol 36
Buprenorphine 34
Dexmedetomidine 34
Milbemycin Oxime + Spinosad 29
Moxidectin 28
Butorphanol 26
Carprofen 25
Atipamezole Hydrochloride 24
Butorphanol Tartrate 24
Capromorelin 24
Ketamine 22
Gabapentin 20
Epinephrine 19
Midazolam 17
Ketamine Hydrochloride 13
Atropine 12
Maropitant 12
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.