Reaction profile

The FDA adverse-event record for wheezing

839 FDA adverse-event reports reference wheezing (VeDDRA 836). See the species, breeds, and drugs most associated with it below.

839
reports citing this reaction
17.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
839
Total Reports
145
Deaths
17.3%
Death Rate

Species Most Affected

Dog 598
Cat 202
Human 15
Horse 11
Cattle 7
Rat 1
Rabbit 1
Guinea Pig 1
Other Reptiles 1
Turtle 1

Breeds Most Affected

Domestic Shorthair 111
Chihuahua 55
Crossbred Canine/dog 52
Terrier - Yorkshire 39
Maltese 26
Shih Tzu 24
Retriever - Labrador 23
Dachshund (unspecified) 22
Unknown 22
Terrier - Jack Russell 19

Associated Drugs

Milbemycin Oxime + Spinosad 98
Maropitant Citrate 54
Moxidectin 46
Carprofen 40
Afoxolaner 37
Selamectin 31
Cefovecin 31
Oclacitinib Maleate 28
Spinosad 26
Imidacloprid + Moxidectin 26
Ivermectin + Pyrantel As Pamoate Salt 23
Bedinvetmab 23
Pimobendan 22
Fluralaner Chew Tablets 21
Nitenpyram 20
Enrofloxacin 19
Prednisone 19
Butorphanol 19
Doxycycline 19
Meloxicam 18

Wheezing Reaction Insights

839 reports name Wheezing; 145 recorded a death outcome (17.3% of reported events, not a population-level mortality rate). VeDDRA code: 836.

By species: Dog (598 reports), Cat (202 reports), Human (15 reports). By breed: Domestic Shorthair (111), Chihuahua (55), Crossbred Canine/dog (52).

Most co-reported drugs: Milbemycin Oxime + Spinosad (98 reports), Maropitant Citrate (54 reports), Moxidectin (46 reports), Carprofen (40 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.