Reaction profile

The FDA adverse-event record for neutropenia

2,374 FDA reports name neutropenia, a high-volume reaction in the CVM extract (VeDDRA 167). Plate stamps and neighbourhood peers follow.

#197 of 2,481
by report volume (all reactions)
2,374
reports citing this reaction
17.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Neutropenia has 2,374 reports now versus 2,272 in that prior snapshot: 102 more (4.5%).

Report change
+102
Death-coded reports
+11
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Neutropenia changes

FDA AER · VeDDRA plate

Code 167 VOL-MID

VOL-MID · DEATH-ELEV · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 2,374 reports
  • DEATH-ELEV 17.2%
  • TOP-DECILE #197/2481
  • PHOTO-FINISH Abnormal breathing
  • SPECIES-DOG Dog · 1,889
  • DRUG-LEAD Oclacitinib Malea… · 631
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abnormal breathing (±7 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Neutropenia

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abnormal breathing · near2381Neutropenia · this reaction2374Dispenser, Abnormal · near2350Rash · near2339Heart murmur · near2328Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Neutropenia

What the FDA AER plate says about Neutropenia

Signature read: 409 death-coded reports is a heavy tail count for Neutropenia in the CVM extract. Report volume is upper-third scale: 2,374 named reports in the openFDA extract. 409 of 2,374 reports were death-coded (17.2% of named reports, not a population mortality rate). Nearest volume peer: Abnormal breathing (±7 reports). Lead species Dog (1,889). Lead co-reported drug Oclacitinib Maleate (631).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Oclacitinib Maleate appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,889
Cat 436
Horse 46
Cattle 1
Alpaca 1
Lynx 1

Breeds Most Affected

Domestic Shorthair 274
Retriever - Labrador 245
Retriever - Golden 133
Crossbred Canine/dog 110
Terrier - Yorkshire 57
Shih Tzu 51
Terrier - Bull - American Pit 50
Shepherd Dog - German 49
Beagle 48
Bulldog - French 47

Associated Drugs

Oclacitinib Maleate 631
Maropitant Citrate 227
Carprofen 180
Ilunocitinib 173
Gabapentin 101
Prednisone 100
Cefovecin 97
Afoxolaner 94
Enrofloxacin 85
Buprenorphine 84
Cyclosporine 79
Toceranib Phosphate 78
Anti-Il31 Mab Mcs Lot #1283563 78
Metronidazole 74
Milbemycin Oxime + Spinosad 73
Moxidectin 70
Famotidine 70
Ivermectin + Pyrantel As Pamoate Salt 70
Meloxicam 54
Robenacoxib 49

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Neutropenia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (2,374 here).

Similar death-coded share

Nearest other reactions by death-coded share (17.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Neutropenia (#197 of 2,481 by report volume); death-coded 17.2%. PlainBreed reaction plate · death-coded report count stamp 409 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →