Reaction profile

The FDA adverse-event record for incoordination

857 FDA adverse-event reports reference incoordination (VeDDRA 1901). See the species, breeds, and drugs most associated with it below.

857
reports citing this reaction
13.9%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
857
Total Reports
119
Deaths
13.9%
Death Rate

Species Most Affected

Dog 669
Cat 155
Horse 14
Cattle 8
Chicken 2
Human 2
Bison 1
Ferret 1
Rabbit 1
Goat 1

Breeds Most Affected

Domestic Shorthair 96
Retriever - Labrador 48
Crossbred Canine/dog 37
Boxer (German Boxer) 33
Chihuahua 32
Retriever - Golden 31
Shepherd Dog - German 27
Terrier - Yorkshire 19
Terrier (unspecified) 17
Shih Tzu 15

Associated Drugs

Milbemycin Oxime + Spinosad 106
Afoxolaner 61
Spinosad 59
Nitenpyram 51
Carprofen 49
Fluralaner Chew Tablets 36
Maropitant Citrate 33
Ivermectin 30
Sarolaner 30
Fluralaner 13.64% 12-Week Chew 30
Pyrantel Pamoate;Sarolaner 30
Selamectin 29
Bedinvetmab 29
Ivermectin + Pyrantel As Pamoate Salt 26
Cefovecin 20
Lufenuron + Milbemycin Oxime 19
Gabapentin 18
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 17
Milbemycin Oxime + Praziquantel 16
Fluralaner Spot-On Solution 16

Incoordination Reaction Insights

857 reports name Incoordination; 119 recorded a death outcome (13.9% of reported events, not a population-level mortality rate). VeDDRA code: 1901.

By species: Dog (669 reports), Cat (155 reports), Horse (14 reports). By breed: Domestic Shorthair (96), Retriever - Labrador (48), Crossbred Canine/dog (37).

Most co-reported drugs: Milbemycin Oxime + Spinosad (106 reports), Afoxolaner (61 reports), Spinosad (59 reports), Nitenpyram (51 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.