Reaction profile

The FDA adverse-event record for incoordination

882 FDA reports name incoordination, a high-volume reaction in the CVM extract (VeDDRA 1901). Plate stamps and neighbourhood peers follow.

#431 of 2,481
by report volume (all reactions)
882
reports citing this reaction
13.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Incoordination has 882 reports now versus 873 in that prior snapshot: 9 more (1.0%).

Report change
+9
Death-coded reports
+3
Death-coded share
+0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Incoordination changes

FDA AER · VeDDRA plate

Code 1901 VOL-MID

VOL-MID · DEATH-ELEV · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 882 reports
  • DEATH-ELEV 13.9%
  • UPPER-Q #431/2481
  • PHOTO-FINISH Gall bladder & bile d…
  • SPECIES-DOG Dog · 684
  • DRUG-LEAD Milbemycin Oxime… · 106
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Gall bladder & bile duct disorder NOS (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Incoordination

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Elevated liver enzyme… · near887Gall bladder & bile d… · near883Incoordination · this reacti…882Intestinal disorder N… · near881Closure, Missing · near878Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Incoordination

What the FDA AER plate says about Incoordination

Signature read: 123 death-coded reports is a heavy tail count for Incoordination in the CVM extract. Report volume is upper-third scale: 882 named reports in the openFDA extract. 123 of 882 reports were death-coded (13.9% of named reports, not a population mortality rate). Nearest volume peer: Gall bladder & bile duct disorder NOS (±1 reports). Lead species Dog (684). Lead co-reported drug Milbemycin Oxime + Spinosad (106).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 684
Cat 163
Horse 16
Cattle 8
Chicken 2
Human 2
Bison 1
Ferret 1
Rabbit 1
Goat 1

Breeds Most Affected

Domestic Shorthair 99
Retriever - Labrador 48
Crossbred Canine/dog 40
Boxer (German Boxer) 34
Chihuahua 32
Retriever - Golden 31
Shepherd Dog - German 27
Terrier - Yorkshire 19
Terrier (unspecified) 18
Beagle 16

Associated Drugs

Milbemycin Oxime + Spinosad 106
Afoxolaner 64
Spinosad 59
Nitenpyram 53
Carprofen 50
Fluralaner Chew Tablets 36
Maropitant Citrate 34
Bedinvetmab 33
Fluralaner 13.64% 12-Week Chew 31
Ivermectin 30
Selamectin 30
Sarolaner 30
Pyrantel Pamoate;Sarolaner 30
Ivermectin + Pyrantel As Pamoate Salt 27
Cefovecin 20
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 20
Lufenuron + Milbemycin Oxime 19
Gabapentin 18
Milbemycin Oxime + Praziquantel 16
Fluralaner Spot-On Solution 16

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Incoordination, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (13.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Incoordination (#431 of 2,481 by report volume); death-coded 13.9%. PlainBreed reaction plate · death-coded report count stamp 123 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →