Reaction profile

The FDA adverse-event record for injection site reaction nos

827 FDA adverse-event reports reference injection site reaction nos (VeDDRA 100). See the species, breeds, and drugs most associated with it below.

827
reports citing this reaction
3.7%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
827
Total Reports
31
Deaths
3.7%
Death Rate

Species Most Affected

Dog 390
Human 257
Cat 91
Horse 44
Cattle 31
Pig 8
Other Reptiles 1
Sheep 1
Alpaca 1
Rabbit 1

Breeds Most Affected

Unknown 260
Dog (unknown) 46
Retriever - Labrador 35
Domestic Shorthair 33
Domestic (unspecified) 30
Retriever - Golden 19
Chihuahua 16
Crossbred Canine/dog 15
Shepherd Dog - German 14
Horse (unknown) 12

Associated Drugs

Carprofen 87
Tulathromycin 83
Tigilanol Tiglate 53
Moxidectin 52
Prednisone 52
Maropitant Citrate 44
Cefovecin Sodium 43
Ceftiofur Crystalline Free Acid 39
Famotidine 39
Melarsomine Dihydrochloride 38
Diphenhydramine 36
Dexmedetomidine Hydrochloride 30
Cefovecin 30
Enrofloxacin 29
Gabapentin 27
Butorphanol 20
Polysulfated Glycosaminoglycan 18
Butorphanol Tartrate 18
Doramectin 17
Melarsomine Dihydrochloride Injection 17

Injection site reaction NOS Reaction Insights

827 reports name Injection site reaction NOS; 31 recorded a death outcome (3.7% of reported events, not a population-level mortality rate). VeDDRA code: 100.

By species: Dog (390 reports), Human (257 reports), Cat (91 reports). By breed: Unknown (260), Dog (unknown) (46), Retriever - Labrador (35).

Most co-reported drugs: Carprofen (87 reports), Tulathromycin (83 reports), Tigilanol Tiglate (53 reports), Moxidectin (52 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.