Reaction profile

The FDA adverse-event record for hematocrit(hct) high, blood

244 FDA adverse-event reports reference hematocrit(hct) high, blood (VeDDRA 99314). See the species, breeds, and drugs most associated with it below.

244
reports citing this reaction
17.2%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
244
Total Reports
42
Deaths
17.2%
Death Rate

Species Most Affected

Dog 229
Cat 14
Horse 1

Breeds Most Affected

Retriever - Labrador 28
Crossbred Canine/dog 16
Dachshund (unspecified) 9
Terrier - Yorkshire 9
Shih Tzu 9
Shepherd Dog - German 9
Beagle 9
Retriever - Golden 8
Domestic Shorthair 7
Pinscher - Miniature 6

Associated Drugs

Milbemycin Oxime + Spinosad 46
Ivermectin + Pyrantel As Pamoate Salt 34
Trilostane 17
Afoxolaner 16
Spinosad 14
Carprofen 13
Maropitant Citrate 11
Fluralaner 13.64% 12-Week Chew 11
Deracoxib 10
Moxidectin 8
Polysulfated Glycosaminoglycan 8
Fluralaner Chew Tablets 7
Cyclosporine A 6
Prednisone 6
Milbemycin Oxime, Lufenuron 6
Milbemycin Oxime + Praziquantel 6
Imidacloprid + Moxidectin 5
Lufenuron + Milbemycin Oxime 5
Meloxicam 5
Tramadol 5

HEMATOCRIT(HCT) HIGH, BLOOD Reaction Insights

244 reports name HEMATOCRIT(HCT) HIGH, BLOOD; 42 recorded a death outcome (17.2% of reported events, not a population-level mortality rate). VeDDRA code: 99314.

By species: Dog (229 reports), Cat (14 reports), Horse (1 reports). By breed: Retriever - Labrador (28), Crossbred Canine/dog (16), Dachshund (unspecified) (9).

Most co-reported drugs: Milbemycin Oxime + Spinosad (46 reports), Ivermectin + Pyrantel As Pamoate Salt (34 reports), Trilostane (17 reports), Afoxolaner (16 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.