Reaction profile

The FDA adverse-event record for voice alteration

106 FDA adverse-event reports reference voice alteration (VeDDRA 1269). See the species, breeds, and drugs most associated with it below.

106
reports citing this reaction
9.4%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
106
Total Reports
10
Deaths
9.4%
Death Rate

Species Most Affected

Dog 67
Cat 32
Human 7

Breeds Most Affected

Domestic Shorthair 22
Retriever - Labrador 11
Unknown 7
Shepherd Dog - German 7
Crossbred Canine/dog 6
Retriever - Golden 3
Domestic Longhair 3
Domestic (unspecified) 2
Dog (unknown) 2
Terrier - Yorkshire 2

Associated Drugs

Carprofen 9
Milbemycin Oxime + Spinosad 9
Bedinvetmab 9
Oclacitinib Maleate 8
Fluralaner Spot-On Solution 6
Selamectin 5
Fluralaner Chew Tablets 5
Spinosad 4
Afoxolaner 4
Eprinomectin + Esafoxolaner + Praziquantel 4
Cefovecin 3
Famotidine 3
Enrofloxacin 3
Moxidectin 3
Imidacloprid + Moxidectin 3
Gabapentin 3
Grapiprant 3
Trilostane 3
Milbemycin Oxime + Praziquantel 3
Frunevetmab 3

Voice alteration Reaction Insights

106 reports name Voice alteration; 10 recorded a death outcome (9.4% of reported events, not a population-level mortality rate). VeDDRA code: 1269.

By species: Dog (67 reports), Cat (32 reports), Human (7 reports). By breed: Domestic Shorthair (22), Retriever - Labrador (11), Unknown (7).

Most co-reported drugs: Carprofen (9 reports), Milbemycin Oxime + Spinosad (9 reports), Bedinvetmab (9 reports), Oclacitinib Maleate (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.