Reaction profile

The FDA adverse-event record for corneal disorder nos

374 FDA adverse-event reports reference corneal disorder nos (VeDDRA 412). See the species, breeds, and drugs most associated with it below.

374
reports citing this reaction
9.1%
death-coded share
Dog
most-affected species
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride
most-associated drug
Verify with FDA CVM →
374
Total Reports
34
Deaths
9.1%
Death Rate

Species Most Affected

Dog 320
Cat 33
Human 9
Cattle 8
Goat 2
Guinea Pig 1
Horse 1

Breeds Most Affected

Shih Tzu 39
Chihuahua 35
Crossbred Canine/dog 21
Domestic Shorthair 19
Retriever - Labrador 12
Unknown 11
Shepherd Dog - German 11
Maltese 10
Dog (unknown) 10
Terrier - Yorkshire 9

Associated Drugs

Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 81
Carprofen 34
Cyclosporine 29
Milbemycin Oxime + Spinosad 28
Prednisone 28
Maropitant Citrate 28
Tobramycin 25
Oclacitinib Maleate 25
Ofloxacin 24
Meloxicam 20
Pilocarpine 20
Artificial Tears 18
Enrofloxacin 17
Ear Cleaner 17
Gabapentin 17
Trilostane 14
Afoxolaner 14
Grapiprant 13
Florfenicol, Terbinafine, Betamethasone Acetate 13
Spinosad 11

Corneal disorder NOS Reaction Insights

374 reports name Corneal disorder NOS; 34 recorded a death outcome (9.1% of reported events, not a population-level mortality rate). VeDDRA code: 412.

By species: Dog (320 reports), Cat (33 reports), Human (9 reports). By breed: Shih Tzu (39), Chihuahua (35), Crossbred Canine/dog (21).

Most co-reported drugs: Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (81 reports), Carprofen (34 reports), Cyclosporine (29 reports), Milbemycin Oxime + Spinosad (28 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.