Reaction profile

The FDA adverse-event record for vaginitis

81 FDA adverse-event reports reference vaginitis (VeDDRA 822). See the species, breeds, and drugs most associated with it below.

81
reports citing this reaction
8.6%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
81
Total Reports
7
Deaths
8.6%
Death Rate

Species Most Affected

Dog 68
Cattle 11
Goat 2

Breeds Most Affected

Retriever - Golden 7
Aberdeen Angus 6
Shepherd Dog - German 5
Crossbred Canine/dog 4
Retriever - Labrador 4
Dog (unknown) 3
Boxer (German Boxer) 3
Bulldog - French 3
Schnauzer (unspecified) 2
Spaniel (unspecified) 2

Associated Drugs

Milbemycin Oxime + Spinosad 16
Progesterone 13
Trilostane 8
Oclacitinib Maleate 7
Milbemycin Oxime + Praziquantel 7
Carprofen 6
Imidacloprid + Moxidectin 4
Afoxolaner 4
Anti-Il31 Mab Mcs Lot #1283563 4
Lotilaner 4
Ivermectin + Pyrantel As Pamoate Salt 3
Prednisone 3
Bedinvetmab 3
Cyclosporine 2
Estriol 2
Maropitant Citrate 2
Enrofloxacin 2
Cefpodoxime Proxetil 2
Fluralaner Chew Tablets 2
Pyrantel Pamoate 2

Vaginitis Reaction Insights

81 reports name Vaginitis; 7 recorded a death outcome (8.6% of reported events, not a population-level mortality rate). VeDDRA code: 822.

By species: Dog (68 reports), Cattle (11 reports), Goat (2 reports). By breed: Retriever - Golden (7), Aberdeen Angus (6), Shepherd Dog - German (5).

Most co-reported drugs: Milbemycin Oxime + Spinosad (16 reports), Progesterone (13 reports), Trilostane (8 reports), Oclacitinib Maleate (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.