Reaction profile

The FDA adverse-event record for increased weight

353 FDA reports name increased weight, a high-volume reaction in the CVM extract (VeDDRA 1049). Plate stamps and neighbourhood peers follow.

#806 of 2,481
by report volume (all reactions)
353
reports citing this reaction
9.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Increased weight has 353 reports now versus 350 in that prior snapshot: 3 more (0.9%).

Report change
+3
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Increased weight changes

FDA AER · VeDDRA plate

Code 1049 VOL-LOW

VOL-LOW · DEATH-PAR · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 353 reports
  • DEATH-PAR 9.3%
  • MID-PACK #806/2481
  • PHOTO-FINISH Nasal congestion
  • SPECIES-DOG Dog · 298
  • DRUG-LEAD Milbemycin Oxime… · 150
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Nasal congestion (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Increased weight

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Pawing · near354Increased weight · this reac…353Nasal congestion · near353Purulent lesion(s) · near353Dry eye · near352Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Increased weight

What the FDA AER plate says about Increased weight

Signature read: 353 reports place Increased weight in the upper third of FDA AER volume (#806 of 2,481). Report volume is upper-third scale: 353 named reports in the openFDA extract. 33 of 353 reports were death-coded (9.3% of named reports, not a population mortality rate). Nearest volume peer: Nasal congestion (±0 reports). Lead species Dog (298). Lead co-reported drug Milbemycin Oxime + Spinosad (150).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 298
Cat 32
Cattle 16
Horse 4
Chicken 2
Turkey 1

Breeds Most Affected

Retriever - Labrador 39
Domestic Shorthair 24
Crossbred Canine/dog 19
Retriever - Golden 14
Chihuahua 13
Beagle 13
Shepherd Dog - German 12
Mixed (Cattle) 12
Pit Bull 11
Dog (unknown) 10

Associated Drugs

Milbemycin Oxime + Spinosad 150
Milbemycin Oxime + Praziquantel 47
Trilostane 26
Milbemycin Oxime 18
Spinosad 16
Oclacitinib Maleate 15
Trenbolone Acetate;Estradiol Benzoate 13
Gabapentin 12
Bexagliflozin 12
Bedinvetmab 12
Imidacloprid + Moxidectin 11
Afoxolaner 11
Maropitant Citrate 10
Lotilaner 10
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 9
Prednisone 9
Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg 8
Ivermectin 8
Ivermectin + Pyrantel As Pamoate Salt 8
Carprofen 8

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Increased weight, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (353 here).

Similar death-coded share

Nearest other reactions by death-coded share (9.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Increased weight (#806 of 2,481 by report volume); death-coded 9.3%. PlainBreed reaction plate · report volume stamp 353 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →