Reaction profile

The FDA adverse-event record for vaginal swelling

133 FDA adverse-event reports reference vaginal swelling (VeDDRA 827). See the species, breeds, and drugs most associated with it below.

133
reports citing this reaction
6.0%
death-coded share
Dog
most-affected species
Estriol
most-associated drug
Verify with FDA CVM →
133
Total Reports
8
Deaths
6.0%
Death Rate

Species Most Affected

Dog 109
Cattle 21
Horse 2
Sheep 1

Breeds Most Affected

Crossbred Canine/dog 12
Terrier - Yorkshire 10
Dog (unknown) 7
Holstein-Friesian also known as Holstein 7
Chihuahua 7
Poodle (unspecified) 5
Dachshund (unspecified) 4
Terrier - Irish Soft-coated Wheaten 4
Beagle 4
Doberman Pinscher 4

Associated Drugs

Estriol 82
Progesterone 10
Estriol Tablets 8
Estradiol 7
Isoflupredone 7
Selenium, Vitamin E 3
Trilostane 2
Milbemycin Oxime + Spinosad 2
Oclacitinib Maleate 2
Glycosaminoglycan Polysulfate 1
Clomipramine 1
Ivermectin 1
Estradiol, Trenbolone Acetate 1
Ivermectin, Pyrantel 1
Selegiline 1
Maropitant 1
Ivermectin, Praziquantel 1
Ampicillin Trihydrate 1
Grapiprant 1
Fish Oil 1

Vaginal swelling Reaction Insights

133 reports name Vaginal swelling; 8 recorded a death outcome (6.0% of reported events, not a population-level mortality rate). VeDDRA code: 827.

By species: Dog (109 reports), Cattle (21 reports), Horse (2 reports). By breed: Crossbred Canine/dog (12), Terrier - Yorkshire (10), Dog (unknown) (7).

Most co-reported drugs: Estriol (82 reports), Progesterone (10 reports), Estriol Tablets (8 reports), Estradiol (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.