Reaction profile

The FDA adverse-event record for lack of efficacy (protozoa) - coccidia

4,076 FDA reports name lack of efficacy (protozoa) - coccidia, a high-volume reaction in the CVM extract (VeDDRA 2803). Plate stamps and neighbourhood peers follow.

#117 of 2,481
by report volume (all reactions)
4,076
reports citing this reaction
5.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lack of efficacy (protozoa) - Coccidia has 4,076 reports now versus 4,039 in that prior snapshot: 37 more (0.9%).

Report change
+37
Death-coded reports
+5
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lack of efficacy (protozoa) - Coccidia changes

FDA AER · VeDDRA plate

Code 2803 VOL-MID

VOL-MID · DEATH-PAR · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 4,076 reports
  • DEATH-PAR 5.9%
  • TOP-DECILE #117/2481
  • PHOTO-FINISH Hypoglycaemia
  • SPECIES-DOG Dog · 3,444
  • DRUG-LEAD Ivermectin + Pyra… · 1,614
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Hypoglycaemia (±16 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Lack of efficacy - Coccidia

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Malaise · near4165Reddening of the skin · near4123Reluctant to move · near4123Hypoglycaemia · near4092Lack of efficacy (pro… · thi…4076Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Lack of efficacy (protozoa) - Coccidia

Lack of efficacy (protozoa) - Coccidia: low death-coded share in the FDA AER plate

Signature read: 4,076 reports place Lack of efficacy (protozoa) - Coccidia in the upper third of FDA AER volume (#117 of 2,481). Report volume is upper-third scale: 4,076 named reports in the openFDA extract. Death-coded share is lower-third: 242 of 4,076 reports (5.9% of named reports). Nearest volume peer: Hypoglycaemia (±16 reports). Lead species Dog (3,444). Lead co-reported drug Ivermectin + Pyrantel As Pamoate Salt (1,614).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Ivermectin + Pyrantel As Pamoate Salt appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 3,444
Cattle 388
Chicken 142
Cat 51
Turkey 19
Goat 14
Sheep 9
Other Birds 4
Rabbit 1
Buffalo 1

Breeds Most Affected

Retriever - Labrador 608
Retriever - Golden 329
Crossbred Canine/dog 279
Beagle 208
Shepherd Dog - German 145
Holstein-Friesian also known as Holstein 142
Chicken (unknown) 102
Shih Tzu 92
Shepherd Dog - Australian 76
Schnauzer - Miniature 69

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 1,614
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 199
Monensin Sodium 197
Milbemycin Oxime, Lufenuron 176
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 167
Milbemycin Oxime + Praziquantel 163
Milbemycin Oxime + Spinosad 162
Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg 138
Pyrantel Pamoate;Sarolaner 120
Lufenuron + Milbemycin Oxime 88
Sulfadimethoxine 80
Moxidectin 80
Ivermectin, Pyrantel 72
Milbemycin 59
Narasin + Nicarbazin 57
Monensin 50
Narasin 50
Lasalocid Sodium 50
Milbemycin Oxime 40
Decoquinate 38

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Lack of efficacy (protozoa) - Coccidia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (4,076 here).

Similar death-coded share

Nearest other reactions by death-coded share (5.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lack of efficacy (protozoa) - Coccidia (#117 of 2,481 by report volume); death-coded 5.9%. PlainBreed reaction plate · report volume stamp 4,076 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →