Reaction profile

The FDA adverse-event record for vesicle

101 FDA adverse-event reports reference vesicle (VeDDRA 1866). See the species, breeds, and drugs most associated with it below.

101
reports citing this reaction
5.9%
death-coded share
Dog
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
101
Total Reports
6
Deaths
5.9%
Death Rate

Species Most Affected

Dog 65
Horse 14
Human 10
Cat 10
Pig 2

Breeds Most Affected

Crossbred Canine/dog 12
Unknown 10
Domestic (unspecified) 8
Retriever - Labrador 8
Retriever - Golden 4
Dachshund (unspecified) 3
Horse (unknown) 3
Quarter Horse 3
Terrier - Boston 3
Terrier - Bull - American Pit 3

Associated Drugs

Selamectin 12
Unspecified 10
Carprofen 9
Spinosad 7
Ivermectin, Praziquantel 6
Ivermectin 6
Betamethasone Valerate, Clotrimazole, Gentamicin Sulfate 4
Imidacloprid, Moxidectin 3
Cyclosporine 3
Meloxicam 3
Moxidectin 3
Maropitant Citrate 3
Diphenhydramine 3
Doramectin 2
Cefovecin Sodium 2
Ivermectin, Pyrantel 2
Cefpodoxime Proxetil 2
Pentobarbital, Phenytoin 2
Spinosad, Milbemycin 2
Milbemycin, Lufenuron 2

Vesicle Reaction Insights

101 reports name Vesicle; 6 recorded a death outcome (5.9% of reported events, not a population-level mortality rate). VeDDRA code: 1866.

By species: Dog (65 reports), Horse (14 reports), Human (10 reports). By breed: Crossbred Canine/dog (12), Unknown (10), Domestic (unspecified) (8).

Most co-reported drugs: Selamectin (12 reports), Unspecified (10 reports), Carprofen (9 reports), Spinosad (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.