Reaction profile

The FDA adverse-event record for injection site complication nos

287 FDA adverse-event reports reference injection site complication nos (VeDDRA 1540). See the species, breeds, and drugs most associated with it below.

287
reports citing this reaction
6.3%
death-coded share
Dog
most-affected species
Tigilanol Tiglate
most-associated drug
Verify with FDA CVM →
287
Total Reports
18
Deaths
6.3%
Death Rate

Species Most Affected

Dog 262
Horse 8
Cattle 7
Cat 5
Human 2
Rabbit 1
Other 1
Pig 1

Breeds Most Affected

Retriever - Labrador 29
Pit Bull 27
Boxer (German Boxer) 23
Dog (unknown) 20
Bulldog - French 15
Chihuahua 14
Retriever - Golden 12
Rottweiler 7
Terrier - Boston 7
Unknown 6

Associated Drugs

Tigilanol Tiglate 208
Diphenhydramine 43
Butorphanol 41
Gabapentin 33
Famotidine 33
Prednisone 29
Dexmedetomidine 27
Maropitant Citrate 25
Atipamezole 23
Buprenorphine 16
Carprofen 13
Dexmedetomidine Hydrochloride 11
Hydromorphone 11
Rabacfosadine 10
Butorphanol Tartrate 9
Propofol 9
Enrofloxacin 7
Ketamine 7
Midazolam 7
Trazodone 7

Injection site complication NOS Reaction Insights

287 reports name Injection site complication NOS; 18 recorded a death outcome (6.3% of reported events, not a population-level mortality rate). VeDDRA code: 1540.

By species: Dog (262 reports), Horse (8 reports), Cattle (7 reports). By breed: Retriever - Labrador (29), Pit Bull (27), Boxer (German Boxer) (23).

Most co-reported drugs: Tigilanol Tiglate (208 reports), Diphenhydramine (43 reports), Butorphanol (41 reports), Gabapentin (33 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.