Reaction profile

The FDA adverse-event record for abnormal urine odour

328 FDA adverse-event reports reference abnormal urine odour (VeDDRA 1966). See the species, breeds, and drugs most associated with it below.

328
reports citing this reaction
10.1%
death-coded share
Dog
most-affected species
Imidacloprid + Moxidectin
most-associated drug
Verify with FDA CVM →
328
Total Reports
33
Deaths
10.1%
Death Rate

Species Most Affected

Dog 278
Cat 42
Horse 5
Human 1
Other Rodents 1
Unknown 1

Breeds Most Affected

Retriever - Labrador 27
Domestic Shorthair 26
Crossbred Canine/dog 18
Chihuahua 18
Shih Tzu 17
Maltese 12
Boxer (German Boxer) 10
Terrier - Yorkshire 10
Dachshund (unspecified) 8
Shepherd Dog - Australian 8

Associated Drugs

Imidacloprid + Moxidectin 72
Trilostane 37
Milbemycin Oxime + Spinosad 27
Carprofen 26
Bedinvetmab 24
Afoxolaner 14
Cyclosporine 10
Meloxicam 9
Cefovecin 9
Oclacitinib Maleate 8
Maropitant Citrate 8
Imidacloprid, Moxidectin 7
Firocoxib 6
Deracoxib 6
Spinosad 6
Bexagliflozin 6
Cyclosporine A 5
Fluralaner Chew Tablets 5
Estriol Tablets 5
Insulin Injectable Vial 5

Abnormal urine odour Reaction Insights

328 reports name Abnormal urine odour; 33 recorded a death outcome (10.1% of reported events, not a population-level mortality rate). VeDDRA code: 1966.

By species: Dog (278 reports), Cat (42 reports), Horse (5 reports). By breed: Retriever - Labrador (27), Domestic Shorthair (26), Crossbred Canine/dog (18).

Most co-reported drugs: Imidacloprid + Moxidectin (72 reports), Trilostane (37 reports), Milbemycin Oxime + Spinosad (27 reports), Carprofen (26 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.