Reaction profile

The FDA adverse-event record for surgical site disorder

321 FDA adverse-event reports reference surgical site disorder (VeDDRA 2107). See the species, breeds, and drugs most associated with it below.

321
reports citing this reaction
15.0%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
321
Total Reports
48
Deaths
15.0%
Death Rate

Species Most Affected

Dog 239
Cat 79
Other 1
Horse 1
Unknown 1

Breeds Most Affected

Retriever - Labrador 38
Domestic Shorthair 37
Retriever - Golden 23
Crossbred Canine/dog 16
Cat (unknown) 15
Shepherd Dog - German 10
Dog (unknown) 9
Doberman Pinscher 7
Boxer (German Boxer) 7
Domestic (unspecified) 7

Associated Drugs

Carprofen 73
Robenacoxib 61
Deracoxib 48
Isoflurane 39
Buprenorphine 35
Oclacitinib Maleate 23
Milbemycin Oxime + Spinosad 22
Meloxicam 21
Tramadol 21
Ketamine 20
Maropitant Citrate 20
Propofol 19
Gabapentin 18
Acepromazine 17
Anesthetic 16
Cefovecin Sodium 15
Butorphanol 15
Bupivacaine 15
Dexmedetomidine 11
Dexmedetomidine Hydrochloride 10

Surgical site disorder Reaction Insights

321 reports name Surgical site disorder; 48 recorded a death outcome (15.0% of reported events, not a population-level mortality rate). VeDDRA code: 2107.

By species: Dog (239 reports), Cat (79 reports), Other (1 reports). By breed: Retriever - Labrador (38), Domestic Shorthair (37), Retriever - Golden (23).

Most co-reported drugs: Carprofen (73 reports), Robenacoxib (61 reports), Deracoxib (48 reports), Isoflurane (39 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.