Surgical site disorder

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VeDDRA Code: 2107

321 adverse event reports referencing this reaction

321
Total Reports
48
Deaths
1500.0%
Death Rate

Species Most Affected

Dog 239
Cat 79
Other 1
Horse 1
Unknown 1

Breeds Most Affected

Retriever - Labrador 38
Domestic Shorthair 37
Retriever - Golden 23
Crossbred Canine/dog 16
Cat (unknown) 15
Shepherd Dog - German 10
Dog (unknown) 9
Doberman Pinscher 7
Boxer (German Boxer) 7
Domestic (unspecified) 7

Associated Drugs

Carprofen 73
Robenacoxib 61
Deracoxib 48
Isoflurane 39
Buprenorphine 35
Oclacitinib Maleate 23
Milbemycin Oxime + Spinosad 22
Meloxicam 21
Tramadol 21
Ketamine 20
Maropitant Citrate 20
Propofol 19
Gabapentin 18
Acepromazine 17
Anesthetic 16
Cefovecin Sodium 15
Butorphanol 15
Bupivacaine 15
Dexmedetomidine 11
Dexmedetomidine Hydrochloride 10

Data Summary

Metric Value
Total reports referencing reaction 321
Reports with fatal outcome 48
Case-fatality rate (reported events) 1500.0%
Species observed 5
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 2107.

Surgical site disorder Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 321 adverse event reports that reference Surgical site disorder as a reaction term, including 48 reports with a death outcome — a 1500.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 2107, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Surgical site disorder appears most frequently in reports for Dog (239 reports), Cat (79 reports), Other (1 reports) — with Dog dominating at 239 entries. Within those species, the breeds most often named alongside this reaction are Retriever - Labrador (38), Domestic Shorthair (37), Retriever - Golden (23). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Surgical site disorder are Carprofen (73 reports), Robenacoxib (61 reports), Deracoxib (48 reports), Isoflurane (39 reports), with Carprofen appearing alongside this reaction in 73 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial