Reaction profile

The FDA adverse-event record for crackles on auscultation

335 FDA adverse-event reports reference crackles on auscultation (VeDDRA 2140). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#828 of 2,481
by report volume (all reactions)
335
reports citing this reaction
50.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Crackles on auscultation has 335 reports now versus 326 in that prior snapshot: 9 more (2.8%).

Report change
+9
Death-coded reports
+7
Death-coded share
+0.7 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Crackles on auscultation changes

FDA AER · VeDDRA plate

Code 2140 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 335 reports
  • DEATH-HOT 50.7%
  • MID-PACK #828/2481
  • PHOTO-FINISH Urolithiasis
  • SPECIES-DOG Dog · 245
  • DRUG-LEAD Maropitant Citrate · 41
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Urolithiasis (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Crackles on auscultation

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Abnormal urine odour · near337Crackles on auscultat… · thi…335Urolithiasis · near335Abnormal red blood ce… · near334Surgical site disorder · near334Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Crackles on auscultation

Crackles on auscultation: high death-coded share in the FDA AER plate

Signature read: Crackles on auscultation's 50.7% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 170 of 335 reports (50.7% of named reports). Nearest volume peer: Urolithiasis (±0 reports). Lead species Dog (245). Lead co-reported drug Maropitant Citrate (41).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 245
Cat 87
Horse 3

Breeds Most Affected

Domestic Shorthair 59
Chihuahua 28
Retriever - Labrador 17
Shih Tzu 16
Terrier - Yorkshire 15
Crossbred Canine/dog 15
Domestic Mediumhair 10
Terrier - Jack Russell 9
Dachshund (unspecified) 9
Terrier - West Highland White 7

Associated Drugs

Maropitant Citrate 41
Furosemide 32
Milbemycin Oxime + Spinosad 31
Cefovecin 29
Carprofen 27
Gabapentin 27
Moxidectin 23
Butorphanol 22
Dexmedetomidine Hydrochloride 22
Prednisone 22
Buprenorphine 19
Bedinvetmab 19
Oclacitinib Maleate 17
Propofol 17
Pimobendan 17
Isoflurane 16
Melarsomine Dihydrochloride 16
Dexamethasone 16
Diphenhydramine 14
Ketamine 13

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Crackles on auscultation, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (335 here).

Similar death-coded share

Nearest other reactions by death-coded share (50.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Crackles on auscultation (#828 of 2,481 by report volume); death-coded 50.7%. PlainBreed reaction plate · death-coded share stamp 50.7% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →