Reaction profile

The FDA adverse-event record for crackles on auscultation

316 FDA adverse-event reports reference crackles on auscultation (VeDDRA 2140). See the species, breeds, and drugs most associated with it below.

316
reports citing this reaction
49.4%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
316
Total Reports
156
Deaths
49.4%
Death Rate

Species Most Affected

Dog 236
Cat 77
Horse 3

Breeds Most Affected

Domestic Shorthair 53
Chihuahua 28
Shih Tzu 16
Retriever - Labrador 15
Crossbred Canine/dog 14
Terrier - Yorkshire 13
Terrier - Jack Russell 9
Dachshund (unspecified) 9
Domestic Mediumhair 8
Terrier - West Highland White 7

Associated Drugs

Maropitant Citrate 33
Milbemycin Oxime + Spinosad 31
Cefovecin 28
Furosemide 25
Moxidectin 23
Carprofen 23
Gabapentin 23
Butorphanol 21
Dexmedetomidine Hydrochloride 21
Prednisone 20
Buprenorphine 18
Oclacitinib Maleate 17
Propofol 17
Bedinvetmab 17
Isoflurane 16
Pimobendan 16
Melarsomine Dihydrochloride 16
Dexamethasone 16
Diphenhydramine 14
Ketamine 12

Crackles on auscultation Reaction Insights

316 reports name Crackles on auscultation; 156 recorded a death outcome (49.4% of reported events, not a population-level mortality rate). VeDDRA code: 2140.

By species: Dog (236 reports), Cat (77 reports), Horse (3 reports). By breed: Domestic Shorthair (53), Chihuahua (28), Shih Tzu (16).

Most co-reported drugs: Maropitant Citrate (33 reports), Milbemycin Oxime + Spinosad (31 reports), Cefovecin (28 reports), Furosemide (25 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.