Reaction profile

The FDA adverse-event record for unsteady gait

1,521 FDA adverse-event reports reference unsteady gait (VeDDRA 1858). See the species, breeds, and drugs most associated with it below.

1,521
reports citing this reaction
11.6%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
1,521
Total Reports
176
Deaths
11.6%
Death Rate

Species Most Affected

Dog 1,250
Cat 250
Horse 11
Cattle 4
Donkey 2
Human 2
Other Rodents 1
Llama 1

Breeds Most Affected

Domestic Shorthair 160
Retriever - Labrador 115
Crossbred Canine/dog 78
Retriever - Golden 66
Shepherd Dog - German 64
Chihuahua 57
Shih Tzu 47
Terrier - Yorkshire 41
Dog (unknown) 41
Boxer (German Boxer) 28

Associated Drugs

Milbemycin Oxime + Spinosad 246
Bedinvetmab 104
Afoxolaner 92
Spinosad 83
Sarolaner 80
Pyrantel Pamoate;Sarolaner 79
Gabapentin 78
Ivermectin + Pyrantel As Pamoate Salt 73
Maropitant Citrate 70
Carprofen 67
Trilostane 58
Milbemycin Oxime + Praziquantel 48
Fluralaner 13.64% 12-Week Chew 47
Fluralaner Chew Tablets 41
Moxidectin 39
Ivermectin 38
Oclacitinib Maleate 37
Grapiprant 33
Buprenorphine 32
Cefovecin 32

Unsteady gait Reaction Insights

1,521 reports name Unsteady gait; 176 recorded a death outcome (11.6% of reported events, not a population-level mortality rate). VeDDRA code: 1858.

By species: Dog (1,250 reports), Cat (250 reports), Horse (11 reports). By breed: Domestic Shorthair (160), Retriever - Labrador (115), Crossbred Canine/dog (78).

Most co-reported drugs: Milbemycin Oxime + Spinosad (246 reports), Bedinvetmab (104 reports), Afoxolaner (92 reports), Spinosad (83 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.