Reaction profile

The FDA adverse-event record for crust

1,528 FDA adverse-event reports reference crust (VeDDRA 1189). See the species, breeds, and drugs most associated with it below.

1,528
reports citing this reaction
6.4%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
1,528
Total Reports
98
Deaths
6.4%
Death Rate

Species Most Affected

Dog 1,136
Cat 368
Cattle 15
Horse 8
Ferret 1

Breeds Most Affected

Domestic Shorthair 240
Retriever - Labrador 113
Crossbred Canine/dog 93
Shepherd Dog - German 60
Retriever - Golden 58
Chihuahua 52
Shih Tzu 35
Dog (unknown) 33
Domestic Longhair 33
Terrier - Yorkshire 24

Associated Drugs

Oclacitinib Maleate 171
Frunevetmab 115
Cefovecin 103
Carprofen 101
Milbemycin Oxime + Spinosad 96
Afoxolaner 88
Prednisone 83
Bedinvetmab 74
Selamectin 73
Trilostane 73
Anti-Il31 Mab Mcs Lot #1283563 69
Maropitant Citrate 63
Fluralaner Chew Tablets 63
Gabapentin 60
Spinosad 51
Imidacloprid + Moxidectin 47
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 46
Pyrantel Pamoate;Sarolaner 46
Moxidectin 45
Cyclosporine 44

Crust Reaction Insights

1,528 reports name Crust; 98 recorded a death outcome (6.4% of reported events, not a population-level mortality rate). VeDDRA code: 1189.

By species: Dog (1,136 reports), Cat (368 reports), Cattle (15 reports). By breed: Domestic Shorthair (240), Retriever - Labrador (113), Crossbred Canine/dog (93).

Most co-reported drugs: Oclacitinib Maleate (171 reports), Frunevetmab (115 reports), Cefovecin (103 reports), Carprofen (101 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.