Reaction profile

The FDA adverse-event record for food refusal

381 FDA adverse-event reports reference food refusal (VeDDRA 2401). See the species, breeds, and drugs most associated with it below.

381
reports citing this reaction
11.8%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
381
Total Reports
45
Deaths
11.8%
Death Rate

Species Most Affected

Dog 291
Cat 73
Horse 9
Cattle 8

Breeds Most Affected

Domestic Shorthair 43
Retriever - Labrador 29
Crossbred Canine/dog 25
Shih Tzu 16
Dog (unknown) 14
Chihuahua 12
Terrier - Yorkshire 12
Retriever - Golden 12
Cat (unknown) 11
Dachshund (unspecified) 8

Associated Drugs

Afoxolaner 33
Fluralaner 13.64% 12-Week Chew 30
Trilostane 28
Ivermectin + Pyrantel As Pamoate Salt 21
Maropitant Citrate 20
Carprofen 19
Fluralaner Chew Tablets 17
Milbemycin Oxime + Spinosad 16
Nitenpyram 14
Fluralaner Spot-On Solution 12
Milbemycin Oxime + Praziquantel 11
Lotilaner 11
Buprenorphine 11
Pyrantel Pamoate;Sarolaner 10
Bexagliflozin 10
Bedinvetmab 10
Grapiprant 9
Monensin Sodium 9
Gabapentin 9
Prednisone 7

Food refusal Reaction Insights

381 reports name Food refusal; 45 recorded a death outcome (11.8% of reported events, not a population-level mortality rate). VeDDRA code: 2401.

By species: Dog (291 reports), Cat (73 reports), Horse (9 reports). By breed: Domestic Shorthair (43), Retriever - Labrador (29), Crossbred Canine/dog (25).

Most co-reported drugs: Afoxolaner (33 reports), Fluralaner 13.64% 12-Week Chew (30 reports), Trilostane (28 reports), Ivermectin + Pyrantel As Pamoate Salt (21 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.