Reaction profile

The FDA adverse-event record for hot spot (pyotraumatic dermatitis)

1,556 FDA adverse-event reports reference hot spot (pyotraumatic dermatitis) (VeDDRA 1200). See the species, breeds, and drugs most associated with it below.

1,556
reports citing this reaction
2.6%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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1,556
Total Reports
40
Deaths
2.6%
Death Rate

Species Most Affected

Dog 1,445
Cat 111

Breeds Most Affected

Retriever - Labrador 190
Retriever - Golden 152
Shepherd Dog - German 87
Domestic Shorthair 77
Crossbred Canine/dog 76
Dog (unknown) 57
Shepherd Dog - Australian 49
Shih Tzu 42
Chihuahua 39
Bichon Frise 39

Associated Drugs

Milbemycin Oxime + Spinosad 318
Afoxolaner 181
Oclacitinib Maleate 96
Carprofen 95
Fluralaner Chew Tablets 94
Spinosad 87
Bedinvetmab 87
Ivermectin + Pyrantel As Pamoate Salt 68
Frunevetmab 57
Imidacloprid + Moxidectin 48
Fluralaner 13.64% 12-Week Chew 48
Trilostane 44
Selamectin 44
Prednisone 43
Milbemycin Oxime + Praziquantel 42
Pyrantel Pamoate;Sarolaner 40
Gabapentin 35
Sarolaner 35
Moxidectin 31
Maropitant Citrate 27

Hot spot (pyotraumatic dermatitis) Reaction Insights

1,556 reports name Hot spot (pyotraumatic dermatitis); 40 recorded a death outcome (2.6% of reported events, not a population-level mortality rate). VeDDRA code: 1200.

By species: Dog (1,445 reports), Cat (111 reports). By breed: Retriever - Labrador (190), Retriever - Golden (152), Shepherd Dog - German (87).

Most co-reported drugs: Milbemycin Oxime + Spinosad (318 reports), Afoxolaner (181 reports), Oclacitinib Maleate (96 reports), Carprofen (95 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.